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Loratadine paste for treating pruritus and prepration method thereof

A technology of loratadine and ointment, applied in the field of ointment and preparation thereof, can solve the problems of unfavorable treatment of allergic skin diseases, low concentration distribution and the like, and achieve the effects of low cost, little skin irritation and simple preparation process

Inactive Publication Date: 2017-10-10
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the relatively low concentration distribution of loratadine in the superficial skin tissue with relatively less blood flow, it is very unfavorable for the treatment of allergic skin diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A loratadine ointment for treating pruritus, characterized in that it consists of the following components in parts by mass: 15 parts of loratadine, 12 parts of sodium caprylate, 60 parts of methanol, and 20 parts of 2-propylene glycol , 2 parts of camphor extract, 5 parts of peppermint extract, 5 parts of sodium stearate, 8 parts of sulfated castor oil, 12 parts of lanolin, 5 parts of white petrolatum;

[0028] The invention also discloses a preparation method of the loratadine ointment for treating pruritus, comprising the following steps:

[0029] (1) Dissolve loratadine and sodium caprate in methanol, and filter and sterilize with a 0.2 μm filter membrane to obtain a mixed system 1;

[0030] (2) Mix camphor extract, peppermint extract, sodium stearate, sulfated castor oil, lanolin, and white petrolatum in 2-propylene glycol, and sterilize at 123°C for 35 minutes to obtain a mixed system 2 ;

[0031] (3) Mixing system 1 and mixing system 2 are uniformly mixed to ob...

Embodiment 2

[0034] A loratadine ointment for treating pruritus, characterized in that it is composed of the following components in parts by mass: 15 parts of loratadine, 14 parts of sodium caprate, 60 parts of ethanol, 10 parts of pentaerythritol, peppermint 5 parts of extract, 5 parts of myristic acid, 10 parts of glyceryl monostearate, 2 parts of chlorhexidine acetate, 3 parts of urea, 10 parts of stearyl alcohol;

[0035] The invention also discloses a preparation method of the loratadine ointment for treating pruritus, comprising the following steps:

[0036] (1) Dissolve loratadine and sodium caprate in ethanol, and filter and sterilize with a 0.25 μm filter membrane to obtain a mixed system 1;

[0037] (2) Mix mint extract, myristic acid, glyceryl monostearate, chlorhexidine acetate, urea, and stearyl alcohol in pentaerythritol, and sterilize at 124°C for 35 minutes to obtain a mixed system 2 ;

[0038] (3) Mixing system 1 and mixing system 2 are uniformly mixed to obtain mixing sy...

Embodiment 3

[0041] A loratadine ointment for treating pruritus, characterized in that it is composed of the following components in parts by mass: 1 part of loratadine, 4 parts of potassium myristate, 50 parts of n-butanol, glycerol 0.5 parts, 2 parts of camphor extract, 5 parts of sulfated castor oil, 10 parts of liquid paraffin

[0042] The invention also discloses a preparation method of the loratadine ointment for treating pruritus, comprising the following steps:

[0043] (1) Dissolve loratadine and potassium myristate in n-butanol, and filter and sterilize with a 0.3 μm filter membrane to obtain a mixed system 1;

[0044] (2) Mix camphor extract, sulfated castor oil, and liquid paraffin in glycerol, and sterilize at 121° C. for 35 minutes to obtain a mixed system 2;

[0045] (3) Mixing system 1 and mixing system 2 are uniformly mixed to obtain mixing system 3, and the gained mixing system 3 is pumped into a shear tank; under normal temperature conditions, open the shearing machine ...

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Abstract

The invention relates to the technical field of ointment and preparation technologies, and in particular relates to loratadine paste for treating pruritus and a preparation method thereof. The loratadine paste for treating pruritus comprises the following components in parts by weight: 1-30 parts of loratadine, 1-30 parts of fatty acid alkali metal salt, 10-80 parts of monohydric alcohol, 0.5-50 parts of polyhydric alcohol, 2-10 parts of accessory and 15-40 parts of auxiliary. The accessory is the extract of camphor or mint; The loratadine paste provided by the invention is quick in transdermal absorption, small in irritation to skin, fewer in used materials, low in cost and simple in prepration technology, can be used for treating swelling and pruritus caused by insect bites, and is suitable for patients with skin allergy at different ages and capable of being popularized for use.

Description

technical field [0001] The invention relates to the technical field of ointment and its preparation, in particular to a loratadine ointment for treating pruritus and a preparation method thereof. Background technique [0002] In recent years, due to climate and environmental changes, various harmful gases, dust and other pollution sources have emerged in large numbers, making them allergens that cause people to have various allergic reactions. Seasonal changes, field work, pollen allergies, inhalation of harmful gases and dust particles, etc., have caused more and more people to suffer from various types of allergic diseases, such as allergic rhinitis, urticaria, skin redness, itching, rashes, etc. Red spots and asthma caused by allergens are very common. Therefore, it is very important to pay attention to environmental changes, strengthen self-care, and develop drugs for the treatment of allergies. Loratadine is an orally effective third-generation antihistamine, which ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4545A61K47/22A61K36/534A61P37/08A61P29/00A61P17/02A61P17/04A61P17/00A61K31/125
CPCA61K9/0014A61K9/06A61K31/125A61K31/4545A61K36/534A61K47/22A61K2300/00
Inventor 朱正标陶元明张汉华李苗苗范小雪
Owner 江苏黄河药业股份有限公司
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