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Medicine composition for improving sleep

A technology for improving sleep and composition, applied in the field of pharmaceutical composition for improving sleep, can solve problems such as insufficient effect, memory impairment, restlessness, etc., and achieve the effect of improving sleep effect

Inactive Publication Date: 2007-03-28
SS PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Regarding the utilization of the anti-melatonin melatonin, there are literatures disclosing that the combination of the anti-melatonin melatonin and clonidine (clonidine) (refer to Patent Document 5), and the administration of the anti-melatonin melatonin alone (refer to Patent Document 6 ), 5-hydroxytryptophan alone (refer to Patent Document 7) as a hypnotic, but its effect is not sufficient
Again, there are also literatures revealing and using derivatives of anti-melatonin melatonin and benzodiazepine (benzodiazepine) as hypnotics, but using benzodiazepine (benzodiazepine) derivatives can cause dizziness, memory impairment, temporary insomnia, Anxiety due to side effects such as dependence

Method used

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  • Medicine composition for improving sleep
  • Medicine composition for improving sleep

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] tablet:

[0112] Use 200 grams of dibenzamine hydrochloride, 90 grams of vine hook extract, 354 grams of lactose, 100 grams of corn starch, 302 grams of crystalline cellulose, 20 grams of cross-linked carmellose sodium (croscarmellose sodium), 24 grams of poly Vinylpyrrolidinone and 10 g of light anhydrous silicic acid were granulated by conventional methods to obtain granules for tableting. After 990 grams of the granules for tableting are mixed with 9 grams of talcum powder and 9 grams of magnesium stearate, the tablets are compressed to obtain 3300 plain tablets with a diameter of 9 millimeters, a thickness of 4.5 millimeters, and a weight of 280 milligrams.

Embodiment 2

[0114] tablet:

[0115] Use 200 grams of dibenzamine hydrochloride, 60 grams of hop extract, 384 grams of lactose, 100 grams of corn starch, 302 grams of crystalline cellulose, 20 grams of croscarmellose sodium, 24 grams of polyvinylpyrrolidone, 10 grams of light anhydrous silicic acid were granulated by conventional methods to obtain granules for tableting. After 990 grams of the granules for tableting are mixed with 9 grams of talcum powder and 9 grams of magnesium stearate, the tablets are compressed to obtain 3300 plain tablets with a diameter of 9 millimeters, a thickness of 4.5 millimeters, and a weight of 280 milligrams.

Embodiment 3

[0117] tablet:

[0118] Use 200 grams of dibenzamine hydrochloride, 60 grams of ginseng extract, 304 grams of lactose, 100 grams of corn starch, 382 grams of crystalline cellulose, 20 grams of croscarmellose sodium, 24 grams of polyvinylpyrrolidone, 10 grams of light anhydrous silicic acid were granulated by conventional methods to obtain granules for tableting. After 990 grams of the granules for tableting are mixed with 9 grams of talcum powder and 9 grams of magnesium stearate, the tablets are compressed to obtain 3300 plain tablets with a diameter of 9 millimeters, a thickness of 4.5 millimeters, and a weight of 280 milligrams.

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Abstract

The present invention provides a medicine composition for improving sleep. Said medicine composition includes the following several portions: antihistamine; one or two kinds of Chinese medicinal materials selected from uncariae uncis cum ramulus, humulus lupulus, ginseng radix, avena sativa, viscum album, glycyrrhizae radix, poria, cnidii rhizome, anemarrhenae rhizome, arisaematis tuber, moutan cortex, potentilla anserine, camomile, piper methysticum and tilia spp.; perfume component; compound selected from vitamin and / or mineral substance; and any one component selected from melatonin compounds.

Description

technical field [0001] The present invention relates to a novel pharmaceutical composition for improving sleep, which contains antihistamine and specific components. Background technique [0002] Many people suffer from insomnia due to social pressure and unfavorable environment. According to surveys, about 80% of modern people have the experience of insomnia, and it is said that more than one out of every five Japanese is troubled by insomnia. [0003] For such insomnia, medicines containing antihistamines as active ingredients are used as general medicines or improvement without prescription in Japan, not to mention the United States, the United Kingdom, Germany, Canada and other European and American countries. A sleeping pharmaceutical composition for reducing temporary insomnia symptoms. [0004] However, according to the state of insomnia, there are sleep disorders (want to sleep but can't sleep well when going to bed, difficulty falling asleep), deep sleep disorders...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P25/20
Inventor 冈田实村田操高桥章金子哲男仓住敏明坂井裕贵大泷宗志奥山泰久村田悌治
Owner SS PHARMA CO LTD
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