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Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating skin mucosa herpes viral infection

A technology of berberine and herpes disease, which is applied in the field of drug application of 13-hexylberberine hydrochloride and 13-hexylpalmatine hydrochloride to treat skin and mucous membrane herpes virus infection, and can solve the problem of no anti-skin herpes virus infection activity and usage issues

Inactive Publication Date: 2007-03-07
CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, HP-13 has no reports on its activity and use against skin herpes virus infection

Method used

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  • Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating skin mucosa herpes viral infection
  • Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating skin mucosa herpes viral infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment one gel

[0018] Weigh:

[0019] HB-13 or HP-13 0.1~2g

[0020] Surfactant 0.5~1g

[0021] Absolute ethanol 5~20ml

[0022] Propanethanol 10~20g

[0023] Carpopol 940 0.5~2g

[0024] Appropriate amount of triethanolamine

[0025] Distilled water up to 100g

[0026] Prepared according to conventional method of gel.

[0027] How to use: Apply an appropriate amount of this gel to the affected area.

Embodiment 2

[0028] The preparation of embodiment two emulsifiable paste

[0029] Weigh:

[0030] HB-13 or HP-13 0.5~2g Glycerin 5~10g

[0031] Cetyl alcohol 6~8g Anhydrous ethanol Appropriate amount

[0032] White petrolatum 8~10g Ethyl ester 0.1g

[0033] Liquid paraffin 8~19g distilled water to 100g

[0034] Monoglyceride 2~5g

[0035] Polyoxyethylene (40) stearate 2~5g

[0036] Make O / W cream according to routine operation of cream.

[0037] How to use: Apply an appropriate amount of this cream to the affected area.

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PUM

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Abstract

The invention relates to a method for using alcaine 13-hexyl berberine and relative alcaine 13-hexyl palmatine to prepare the drug that treats herpesvirus infection on skin mucosa. And said two compounds have strong functions to resist HSV, I, II herpesvirus. And their restrain density (IC50) of external resist HSV-1 type and HSV-2 type is 0.78-1.56 mug / ml. And the 0.5% 13-hexyl berberine or alcaine 13-hexyl palmatine, or 1% emulsion can treat bleb, stronger than 3% assili lovou.

Description

technical field [0001] The present invention is about the compound 13-hexylberberine hydrochloride (abbreviated as HB-13) and its congener 13-hexylpalmatine hydrochloride (abbreviated as HP-13) to prepare skin and mucous membrane anti-herpes virus (herpes simplex type 1, type 2 and herpes simplex). Drug application for herpes zoster) infection. Background technique [0002] 13-Hexylberberine Hydrochloride (HB-13), molecular formula C 26 h 31 NO 4 HCl, molecular weight 457.98, has the following chemical structure: [0003] [0004] The above-mentioned HB-13 is composed of the 13th-H in the molecule of the parent compound berberine hydrochloride (abbreviated as Bo) by hexyl-C 6 h 13 The derivative obtained by substitution is obtained by reacting Bo with sodium borohydride dilute lye in aqueous medium to obtain dihydroberberine, and then reacting n-hexanal and dihydroberberine in acetic acid ethanol solution to generate crude product HB-13, Then it is further refined. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61K9/00A61P31/22
Inventor 郑家润张崇璞李耐三李新宇唐美育高纪伟徐兰芳
Owner CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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