Extended release pharmaceutical compositions of divalproex sodium
A technology of divalproex sodium and slow-release drugs, applied in drug combinations, active ingredients of anhydrides/acids/halides, nervous system diseases, etc.
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[0049] The divalproex sodium, lactose, Methocel K-15M CR and Methocel E-5 were mixed in a rapid mixing granulator. Granules were prepared by adding granulation fluid (purified water) to the drug / polymer / lactose mixture. The resulting granules are dried in a fluid bed dryer and sieved through a suitable sieve. The dried granules are mixed with talc, colloidal silicon dioxide and magnesium stearate, compressed into tablets of suitable size and coated with PEG 400 and an aqueous Opadry dispersion.
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