A composition for cartilage therapeutics and using method thereof

Abstract

A cartilage therapeutic composition is developed for clinical transplantation into articulatio genu (knee joints) or ankle joints. It has clinical significance for symptomatic cartilage defects of the femoral condyle (medial, lateral, or trochlear) and bone cartilage defects of the talus (anklebone) in human or animal hosts, The cartilage therapeutic composition comprises a mixture of components of chondrocytes isolated and expanded or differentiated from a host such as a human or animal, and thrombin and a fibrinogen matrix containing fibrinogen. An application of the cartilage therapeutic composition is that a mixture of thrombin, chondrocyte components and a fibrinogen matrix is injected into a cartilage defect region followed by solidification therein. It provides rapid healing and effective regeneration of cartilage without surgical operation. It has the merits of safety and simplicity by allowing the use of an arthroscope for transplantation.

Description

technical field [0001] The present invention relates to a cartilage treatment composition and its use method. The cartilage treatment composition can be clinically implanted into the knee joint or ankle joint, especially implanted into the femoral joint (middle, lateral or trochlear portion) of a human or animal host Clinically obvious cartilage defect areas with symptoms and cartilage defect areas of the ankle (ankle bone). Background technique [0002] Generally speaking, cartilage tissue constitutes the joints of vertebrates, and once damaged, it cannot be regenerated to its original state in vivo. [0003] When the cartilage tissue in a joint is damaged, normal daily activities can be limited due to severe pain. Initial damage to articular cartilage tissue can progress to a chronic condition called fatal degenerative arthritis, which interferes with normal life. [0004] Meanwhile, to treat articular cartilage damage, there is recently a treatment method that softens t...

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Problems solved by technology

[0015] In addition, autologous chondrocyte transplantation has various disadvantages, such as a large incision on the knee due to collection of the periosteum, possible leakage of chondrocyte therapeutic agents due to incomplete suturing between the surgical site and the periosteum, extrabone The suture between the membrane and the joint defect area is too time-consuming, etc.

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