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Preparing method of scalded leech medicine granule

A technology of formula granules and scalding leeches, which is applied in the direction of medical raw materials derived from leeches/worms, bulk transportation, cardiovascular system diseases, etc., can solve the problems of low drug concentration, ineffective curative effect, easy sticking to rollers, etc., and achieve drug High concentration, obvious curative effect, solve the effect of sticking roller

Active Publication Date: 2006-11-08
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prepared preparation has low drug concentration and large dosage, so the curative effect is not obvious
Traditional Chinese medicine formula granules are dry extract powder made of Chinese herbal medicine pieces extracted with water and spray-dried. Dry extract powder is easy to stick to the roller after being pressurized and heated during the dry granulation process. Therefore, the traditional dry granulation method used in the food industry cannot Simple application in traditional Chinese medicine formula granules
Hot leech formula granule is one of the traditional Chinese medicine formula granules. At present, there is no literature report on the preparation process of hot leech formula granule

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] Take 6000g of hot leech decoction pieces, add water to decoct twice, add 12 times the amount of water for the first decoction, decoct for 2 hours, add 10 times the amount of water for the second decoction, decoct for 1.5 hours, combine the decoctions, and filter; the filtrate is in a vacuum of 0.08 Concentrate under reduced pressure under Mpa to a clear paste with a relative density of 1.09 (55°C); spray-dry with an inlet air temperature of 170°C and an outlet air temperature of 85°C to make 852g of dry extract powder, add dextrin or lactose or maltodextrin 148g, add 5g of magnesium stearate, mix well; granulate by law, the main pressure of the roll is 25kg / cm 2 , roll side pressure 15kg / cm 2 1. The rolling speed is 18r / min, the feeding speed is 130r / min, the granules are sized, and sieved to make 1000g of 18-40 mesh granules, which are packaged to obtain final product.

example 2

[0022] Take 6000g of hot leech decoction slices, add water to decoct twice, add 10 times the amount of water for the first decoction, decoct for 1.5 hours, add 8 times the amount of water for the second decoction, decoct for 1 hour, combine the decoctions, and filter; the filtrate is in a vacuum of 0.07 Concentrate under reduced pressure under Mpa to a clear paste with a relative density of 1.08 (58°C); spray-dry with an inlet air temperature of 175°C and an outlet air temperature of 85°C to make 830g of dry extract powder, add dextrin or lactose or maltodextrin 170g, add 6g of magnesium stearate, mix well; dry granulation, the main pressure of the roll is 23kg / cm 2 , roll side pressure 18kg / cm 2 1. Roll speed 17r / min, feeding speed 120r / min, granulate, sieve, make 1000g of 18-40 mesh granules, pack separately, to get final product.

example 3

[0024] Take 6000g of hot leech decoction pieces, add water and decoct twice, add 8 times the amount of water for the first decoction, decoct for 1 hour, add 6 times the amount of water for the second decoction, decoct for 0.5 hours, combine the decoctions, and filter; the filtrate is in a vacuum of 0.08 Concentrate under reduced pressure under Mpa to a clear paste with a relative density of 1.08 (56°C); spray-dry with an inlet air temperature of 170°C and an outlet air temperature of 90°C to make 800g of dry extract powder, add dextrin or lactose or maltodextrin 200g, add 8g of magnesium stearate, mix well; dry granulation, the main pressure of the roll is 23kg / cm 2 , roll side pressure 17kg / cm 2 1. The rolling speed is 19r / min, the feeding speed is 140r / min, granulated, sieved, made into 1000g of 18-40 mesh granules, and packed separately.

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Abstract

The present invention relates to preparation process of leech medicine granule. The preparation process includes preparing scalded leech piece, decoction, filtering, decompression concentrating the filtrate to obtain extractum, spray drying to obtain powder, mixing with magnesium stearate and one of dextrin, lactose and maltodextrin in certain weight proportion, and pelletizing with roller to form 18-40 mesh granule. The leech medicine granule contains amino nitrogen not less than 10 mg / g, active antitrombase not less than 16.0 U / g and sarkin not less than 2 mg / g.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine formula granule, in particular to a preparation method of a scalding leech formula granule. It belongs to the technical field of preparation of traditional Chinese medicine formula granules. Background technique: [0002] Leech is a commonly used traditional Chinese medicine for promoting blood circulation and removing blood stasis. It has the effects of breaking blood, removing blood stasis, and dredging menstruation. It is widely used clinically for cerebrovascular disease, coronary heart disease, angina pectoris, cor pulmonale, bronchial asthma, chronic glomerulonephritis, etc. Leeches mainly contain proteins, polypeptides, 17 kinds of amino acids and 14 kinds of trace elements. Components that directly act on the blood coagulation system mainly include thrombin inhibitors such as hirudin, bufrudin, and haemadin; protein inhibitors and other active components include cellolysin (Hementerin) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/62A61K9/16A61P9/10A61P11/06A61P13/12
Inventor 徐以亮王元清周嘉琳徐海波朱文荣
Owner JIANGYIN TIANJIANG PHARMA
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