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Chinese medicinal preparation for treating heart cerebrovascular disease and making method thereof

A technology of cardiovascular and cerebrovascular diseases and traditional Chinese medicine preparations, which is applied in the field of medicine and can solve problems such as injection dosage forms that have not been seen.

Active Publication Date: 2006-11-01
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Judging from the marketed Chinese patent medicines for the treatment of cardiovascular and cerebrovascular diseases and ischemic stroke, there are no injection dosage forms made with the above two kinds of Chinese herbal medicines as prescriptions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Preparation of freeze-dried powder injection

[0102] (1) Get 1.67Kg of Radix Paeoniae Rubra, add 18 times the amount of water, heat and extract three times, each time for 2 hours, the extracts are combined, filtered, the filtrate is concentrated to a relative density of 1.17, and ethanol is added to make the alcohol content reach 75%. Add 10% alkali to make the pH value of the solution 8, refrigerate for 24 hours, and filter; recover ethanol from the filtrate until it has no alcohol smell, add water to dilute to a relative density of 1.10-1.20, stir well, filter, and put the filtrate on a macroporous adsorption resin chromatography column, Wash with water until the eluate has no reducing sugar reaction, then elute with 70% ethanol, collect the ethanol eluate, recover ethanol under reduced pressure, and dry in vacuum to obtain 40.2 g of total glucosides of paeony, including 13.0 g of paeoniflorin.

[0103] (2) Take 1.33Kg of gardenia, add 24 times of water, heat and ext...

Embodiment 2

[0106] Preparation of Liquid Injections

[0107] (1) Get 1.67Kg of Radix Paeoniae Rubra, add 18 times the amount of water, heat and extract three times, each time for 2 hours, the extracts are combined, filtered, the filtrate is concentrated to a relative density of 1.17, and ethanol is added to make the alcohol content reach 75%. Add 10% alkali to make the pH value of the solution 8, refrigerate for 24 hours, and filter; recover ethanol from the filtrate until it has no alcohol smell, add water to dilute to a relative density of 1.10-1.20, stir well, filter, and put the filtrate on a macroporous adsorption resin chromatography column, Wash with water until the eluate has no reducing sugar reaction, then elute with 70% ethanol, collect the ethanol eluate, recover ethanol under reduced pressure, and dry in vacuum to obtain 40.2 g of total glucosides of paeony and 13.0 g of paeoniflorin.

[0108] (2) Take 1.33Kg of gardenia, add 24 times of water, heat and extract three times, e...

Embodiment 3

[0111] preparation of tablets,

[0112] Step 1 and Step 2 are as in Step (1) and Step (2) of Examples 1 and 2, and Step (3) is to take one-third of the above-mentioned (1)-(2) compositions and add pharmaceutical excipients , prepared into 1000 tablets according to the conventional technology of photographic agents, and can be coated if necessary.

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PUM

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Abstract

A Chinese medicine for treating cardiovascular and cerebrovascular diseases is prepared from red peony root and capejasmine fruit. The prescription and preparing process of its injection and its other clinical forms are also disclosed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a traditional Chinese medicine preparation prepared from two traditional Chinese medicinal materials of Radix Paeoniae Rubra and Fructus Gardeniae, in particular to the preparation process of the effective parts of the two traditional Chinese medicinal materials. The invention also relates to the prescription and molding of injections Technology and clinical dosage forms. technical background [0002] Ischemic stroke is a kind of cardiovascular and cerebrovascular diseases. Although there are many drugs for the treatment of cardiovascular and cerebrovascular diseases in the world at present, due to the drug resistance, dependence and high price of western medicines, and the development of traditional Chinese medicine formulations and drug effects is relatively lagging behind, it is still necessary to continuously develop new high-efficiency, low-toxicity, and low-cos...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61K9/00A61P9/10
Inventor 李琪
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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