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Earthworm acidic-part medicine for treating cough asthma disease and preparing method

A technology for acidic parts and cough and asthma, applied in the field of medical engineering, can solve problems such as difficult to effectively control drug quality, difficult to establish drug quality standards, and unclear chemical substance basis of active ingredients, so as to facilitate quality control and clear chemical composition , The effect of facilitating patients to take medication

Inactive Publication Date: 2006-10-25
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the application form of earthworm, earthworm powder or earthworm extract has not been separated and removed, and the effective parts and ineffective parts of earthworm are used in combination. The chemical substance basis of the active ingredients is not clear, and it is difficult to establish quality standards for drugs. Effectively control drug quality

Method used

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  • Earthworm acidic-part medicine for treating cough asthma disease and preparing method
  • Earthworm acidic-part medicine for treating cough asthma disease and preparing method
  • Earthworm acidic-part medicine for treating cough asthma disease and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Screening the effective parts of Dilong antiasthma

[0023] Three parts of Earthworm were prepared respectively, including the acidic part of Earthworm, the alkaline part of Earthworm, and the water-extracted and alcohol-precipitated part of Earthworm (for the preparation process, see figure 1 ). Then observe the relaxation effect of the three extraction sites on the increase of guinea pig tracheal smooth muscle tension caused by carbachol (CCh) and histamine (His), and the inhibitory effect on the increase of short-circuit current in the rat tracheal epithelium caused by CCh (inhibition of sputum secretion effect). The relaxation effect of 3 earthworm extract parts on tracheal smooth muscle figure 2 and image 3 , the results show that the three kinds of earthworm extract parts have weak relaxation effects on guinea pig isolated tracheal smooth muscle contraction caused by 10μM carbachol, and the acid part of earthworm has the largest relaxation rate, whi...

Embodiment 2

[0026] Example 2 Preparation of acid fraction of earthworm

[0027] Preparation:

[0028] Take 1000g of dried Earthworm, crush it into coarse powder, add 5 times the amount of Earthworm to soak at room temperature for 3 hours, filter; add 4 times the amount of Earthworm to soak in water at 45°C for 2 hours, filter, repeat this operation once, Filtrate, combine the filtrates three times, centrifuge at low speed for 9 minutes, take the centrifuged supernatant, concentrate under reduced pressure to 4 times the volume of the earthworm dosage, then add 95% ethanol to make the alcohol content reach 70%, let it stand for 16 hours, centrifuge, and take the supernatant liquid, the supernatant was concentrated under reduced pressure to 3 times the volume of the earthworm dosage. Pass it through strongly basic anion exchange resin (resin column diameter height ratio 1: 10, resin consumption is 3 times of earthworm). First elute with 9 times the column volume of deionized water until th...

Embodiment 3

[0031] Example 3 Preparation of acid fraction of earthworm

[0032] Preparation:

[0033] Take 1000g of dried Earthworm, crush it into coarse powder, add 2 times the amount of Earthworm to soak at room temperature for 2 hours, filter; add 2 times the amount of Earthworm to soak at 40°C for 1 hour, filter, repeat this operation once, Filter, combine the filtrates three times, centrifuge at low speed for 3min, take the centrifuged supernatant, concentrate under reduced pressure to 2 times the volume of earthworm, then add 95% ethanol to make the alcohol content reach 70%, let stand for 8h, centrifuge, take the supernatant liquid, the supernatant was concentrated under reduced pressure to 2 times the volume of the earthworm dosage. Pass it through strongly basic anion exchange resin (resin column diameter height ratio 1: 10, resin consumption is 2 times of earthworm). First elute with 3 times the column volume of deionized water until the eluate is neutral and colorless, then elu...

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Abstract

The present invention relates to an earthworm acid region medicine for curing cough and asthma diseases and its preparation method. Said earthworm acid region medicine contains fatty acid, amino acid and purine compound, and can be used for curing the diseases of asthma and chronic bronchitis, etc. Its preparation method includes the following steps: using strong base anion-exchange resin to adsorb aqueous extract of earthworm, then using dilute hydrochloric acid or alcohol-containing dilute hydrochloric acid to make elution.

Description

technical field [0001] The invention relates to a medicine in the technical field of medical engineering and a preparation method thereof, in particular to a medicine for the acid part of earthworm for treating cough and asthma and a preparation method thereof. Background technique [0002] Asthma is an immunoallergic disease characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation caused by multiple factors. Chronic bronchitis (referred to as chronic bronchitis) is chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues. The main symptoms of clinical manifestations such as chronic bronchitis and obstructive pulmonary disease are "cough, phlegm, wheezing", which doctors are accustomed to abbreviate as chronic cough and asthma. Cough and asthma is a common disease that seriously endangers the health of the masses, and frequently-occurring diseases. There is currently no specific treatment for coug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/62A61P11/06A61P11/14
Inventor 贾伟徐朝晖赵爱华褚襄萍
Owner SHANGHAI JIAO TONG UNIV
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