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Pill preparation with ultramicro powder and preparation method thereof

A technology for dropping pills and preparations, applied in the field of traditional Chinese medicine dropping pills and their preparation, can solve the problems of low bioavailability, long disintegration time of Guanxinjing Capsules, affecting the curative effect of Guanxinjing Capsules, etc.

Inactive Publication Date: 2006-10-04
海口绿科南药研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The disintegration time of Guanxinjing Capsules is long, and because the capsules contain raw medicinal powder, the absorption is poor and the bioavailability is low, which affects the curative effect of Guanxinjing Capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0038] Superfinely pulverize 6.25g Chuanxiong, 2.5g Sanqi, and 1.25g Ginseng; take 12.5g Salvia, 6.25g Radix Paeoniae Rubra, 6.25g Safflower, 6.25g Polygonatum odoratum, add 15 times the amount of water to decoct twice, each time 2 After hours, the filtrates were combined, concentrated to a thick paste, dried under reduced pressure, and ultrafinely pulverized. Take 45g of polyethylene glycol 6000, heat and melt in a water bath, add superfine powder of mixed extracts of salvia miltiorrhiza, red peony root, safflower and Polygonatum odoratum, stir evenly, add chuanxiong, notoginseng, ginseng superfine powder, stir well Then add 0.5g styrax and 0.125g borneol, stir evenly and transfer to the liquid storage bottle, airtight and keep warm at 80°C, use methyl silicone oil as coolant, and make 1000 drop pills, to get final product.

preparation example 2

[0040] Superfinely pulverize 6.25g Chuanxiong, 2.5g Sanqi, and 1.25g Ginseng; take 12.5g Salvia, 6.25g Radix Paeoniae Rubra, 6.25g Safflower, 6.25g Polygonatum odoratum, add 15 times the amount of water to decoct twice, each time 2 After hours, the filtrates were combined, concentrated to a thick paste, dried under reduced pressure, and ultrafinely pulverized. Take 40g of polyethylene glycol 4000, heat and melt in a water bath, add 0.5g of styrax, 0.125g of borneol, stir evenly, add superfine powder of mixed extracts of salvia miltiorrhiza, red peony root, safflower, and Polygonatum odoratum, stir evenly and add Ligusticum chuanxiong, notoginseng, ginseng superfine powder, stir evenly, transfer to the liquid storage bottle, seal and keep warm at 75°C, use liquid paraffin as coolant, make 1000 drop pills, and get ready.

preparation example 3

[0042] Superfinely pulverize 8.33g Rhizoma Chuanxiong, 3.33g Panax notoginseng, and 1.67g Ginseng; take 16.67g Salvia Miltiorrhiza, 8.33g Radix Paeoniae Rubra, 8.33g Safflower, 8.33g Polygonatum odoratum, add 12 times the amount of water to decoct twice, each time 2 After hours, the filtrates were combined, concentrated to a thick paste, dried under reduced pressure, and ultrafinely pulverized. Take 50g of polyethylene glycol 4000 and 5g of polyethylene glycol 400, heat and melt in a water bath, add 0.67g of styrax, 0.17g of borneol, stir evenly, add the mixed extracts of salvia miltiorrhiza, red peony root, safflower, and Polygonatum odoratum for super Fine powder, stir evenly, add Ligusticum chuanxiong, Panax notoginseng, ginseng ultrafine powder, stir evenly, transfer to a liquid storage bottle, seal and keep warm at 85°C, use liquid paraffin as a coolant, make 1000 drop pills, and get ready.

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PUM

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Abstract

The invention provides a dripping pill preparation and its preparing process, wherein the preparation is prepared from raw materials including root of red rooted saliva, radix paeoniae rubrathe, Ligusticum wallichii, safflower, fragrant solomonseal rhizome, notoginseng, gen-seng, liquidambar orientalis mill and borneo camphor. The invention can realize reduced disintegrating period and increase bioavailability.

Description

technical field [0001] The invention relates to a traditional Chinese medicine dripping pill preparation and a preparation method thereof. The preparation is composed of salvia miltiorrhiza, red peony root, chuanxiong, safflower, polygonatum polygonatum, notoginseng, ginseng, styrax and borneol. Background technique [0002] Guanxinjing Capsule (WS-10594-(ZD-0594)-2002) has been used in clinical practice. It is a compound preparation of traditional Chinese medicine. It is made of Danshen, Chishao, Chuanxiong, Safflower, Polygonatum, Panax notoginseng, Ginseng, Styrax, and Borneol. , has the effects of promoting blood circulation and removing blood stasis, nourishing qi and unblocking the meridian, etc. It is clinically used for chest pain, shortness of breath, palpitation and coronary heart disease caused by qi deficiency and blood stasis. [0003] The disintegration time of Guanxinjing Capsules is long, and because the capsules contain raw medicinal material powder, the abs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/20A61P9/10A61K31/045
Inventor 滕厚雷
Owner 海口绿科南药研究开发有限公司
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