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Surgical flush fluid and its preparing process and application

A technique for surgical irrigating liquid and irrigating liquid, which is applied in the directions of surgical drugs, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problem of no prevention of surgical adhesions, etc., and achieves no toxic side effects, prevention of surgical adhesions, and stability. Good results

Inactive Publication Date: 2006-10-04
刘万顺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the irrigating fluid used clinically can only be used for rinsing the surgical site, and has no effect on preventing surgical adhesions. Surgical irrigating fluids with the functions of surgical rinsing and preventing surgical adhesions have not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Preparation of rinse solution containing carboxymethyl chitosan: Weigh 3.0 g of carboxymethyl chitosan, place it in a clean saline bottle, add 100 ml of solvent saline, stir to dissolve, and sterilize at 121°C for 20 minutes with damp heat , to obtain surgical irrigating fluid (A) containing carboxymethyl chitosan.

Embodiment 2

[0011] Preparation of washing solution containing carboxymethyl cellulose: Weigh disodium hydrogen phosphate (Na 2 HPO 4 ·2H 2 O) 0.0162 moles (analytically pure, the same below), sodium dihydrogen phosphate (NaH 2 o 4 ·2H 2 (0) 0.0038 moles, put in a beaker, add 1000 ml of sterile distilled water, stir and dissolve to obtain a phosphate buffer solution with a total molar concentration of 0.02M pH7.4. Weigh NaHCO 3 0.84g, 21.05g of sodium gluconate, and 16.04g of mannitol were added to the above-mentioned buffer respectively, and stirred to dissolve. Membrane filtration (Ф0.22 μm) is carried out under aseptic conditions into a sterile pyrogen-free physiological saline bottle, and sterilization and pyrogen removal are performed to obtain a solvent physiological balance solution. Weigh 0.5 g of sterile pyrogen-free carboxymethyl cellulose, place it in a clean sterile pyrogen-free physiological saline bottle, add 100 ml of physiological balance solution under aseptic condit...

Embodiment 3

[0014] Preparation of surgical irrigating solution containing carboxymethyl cellulose and carboxymethyl chitin: weigh 0.5 g of sterile carboxymethyl cellulose and 0.5 g of sterile carboxymethyl chitin, respectively, and place in clean sterile saline In the bottle, under aseptic conditions, add 250 ml of sterile solvent Ringer's solution, stir and dissolve to obtain the surgical washing solution (C) containing carboxymethyl cellulose and carboxymethyl chitin.

[0015] Changing carboxymethyl cellulose and carboxymethyl chitin into any two of carboxymethyl cellulose, carboxymethyl chitosan and carboxymethyl chitin can also achieve the same effect.

[0016] In the above three embodiments, the solute used to prepare the surgical flushing solution is any one of carboxymethyl cellulose, carboxymethyl chitosan, and carboxymethyl chitin, or two of the three combination can achieve the same effect. The solvent used can be water for injection, normal saline, Ringer's solution flushing s...

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PUM

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Abstract

The invention provides a flushing fluid for surgery, which comprises solute and solvent, wherein the solute is one or two selected from cellulose glycollic ether, carboxymethyl chitosan or carboxymethyl chitosan, the solvent being water for injection, physiological saline solution, sodium chloride flushing fluid, mannitol flushing fluid, glucose flushing fluid, chlorhexidine flushing fluid, gentamicin physiological saline flushing fluid, active iodine flushing fluid, benzalkonium bromide flushing fluid, aminoacetic acid flushing fluid, metronidazole flushing fluid or physiological equilibrium liquid comprising phosphates cushioning liquid, NaHCO3, sodium gluconate and mannitol.

Description

technical field [0001] The invention relates to a surgical flushing liquid and its preparation method and application, in particular to a surgical flushing liquid for preventing surgical adhesions and its preparation method and application. Background technique [0002] The inventor disclosed a carboxymethyl chitosan in the patent No. ZL92106578.7, which is a milky white or light yellow powder, easily soluble in water, and becomes a transparent viscous colloid solution after being dissolved in water . The feasibility of carboxymethyl chitosan as a medicine for treating gastritis and gastric ulcer is further disclosed in the patent No. ZL01107718.2, and it is believed that it has the effect of treating gastritis and gastric ulcer as a medicine. The inventor disclosed a water-soluble medical chitosan preparation and a preparation method in the patent No. ZL00111646.0. In the patent application whose application number is 200510045472.X, the application of hydrogels made of c...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K9/08A61P41/00
Inventor 刘万顺顾其胜侯春林韩宝芹
Owner 刘万顺
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