Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition using hydrochlorothiazide and benazepril hydrochloride as active ingredients, its preparation method and use

A technology of benazepril hydrochloride and hydrochlorothiazide, which is applied in the field of medicine and can solve problems such as the incomplete understanding of the mechanism of action

Inactive Publication Date: 2006-09-06
BEIJING RUNDEKANG MEDICAL TECH CO LTD
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its mechanism of action is not fully understood

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Embodiment 1 hydrochlorothiazide and benazepril hydrochloride tablet

[0014] components

Dosage

Hydrochlorothiazide

Benazepril Hydrochloride

microcrystalline cellulose

pregelatinized starch

lactose

CMS-Na

Micropowder silica gel

Magnesium stearate

95% ethanol

12.5g

10g

60g

25g

30g

4g

4g

2.5g

Appropriate amount

Co-made

1000 pieces

[0015] Preparation:

[0016] Pass hydrochlorothiazide, benazepril hydrochloride, microcrystalline cellulose, pregelatinized starch, and lactose through 80-mesh sieve respectively, after mixing evenly, add 95% ethanol to make soft material, granulate with 20-mesh sieve, dry, and 18-mesh sieve For granulation, add magnesium stearate, CMS-Na, and micropowder silica gel, mix well, and press a suitable die to form a tablet.

Embodiment 2

[0017] Embodiment 2: hydrochlorothiazide and benazepril hydrochloride capsules

[0018] components

Dosage

Hydrochlorothiazide

Benazepril Hydrochloride

Dextrin

starch

CMS-Na

2% PVP-k30 aqueous solution

Magnesium stearate

12.5g

10g

20g

60g

2.0g

Appropriate amount

1.5g

[0019] Preparation:

[0020] Pass hydrochlorothiazide, benazepril hydrochloride, dextrin, and starch through 80-mesh sieve respectively, and after mixing evenly, add 0.5% PVP-k30 aqueous solution to make soft material, granulate with 24-mesh sieve, dry, granulate with 24-mesh sieve, add The prescribed amount of CMS-Na and magnesium stearate is mixed evenly and packed into suitable capsule shells.

Embodiment 3

[0021] Embodiment 3: hydrochlorothiazide and benazepril hydrochloride dispersible tablet

[0022] components

Dosage

Hydrochlorothiazide

Benazepril Hydrochloride

microcrystalline cellulose

lactose

CMS-Na

50% ethanol solution

Co-made

12.5g

10g

80g

40g

9g

Appropriate amount

1000 pieces

[0023] Preparation:

[0024] Pass hydrochlorothiazide, benazepril hydrochloride, microcrystalline cellulose, and lactose through 80-mesh sieve respectively, mix well, add 50% ethanol solution to make soft material, granulate with 24-mesh sieve, dry, granulate with 20-mesh sieve, add The disintegrating agent CMS-Na, after mixing evenly, compressing the tablet, that is to say.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

This invention is about a medicine composition taking hydrochlorothiazide and hydrochloric acid benapuli as active component and its preparing method and usages. It takes hydrochlorothiazide and hydrochloric acid benapuli as medicine active component, and is formed by mixing acceptable finding. It can be used to cure miscellaneous tapping hypertensions. It uses hydrochlorothiazide and hydrochloric acid benapuli as raw materials and adds some findings those have specified kinds and ratios. Developing troche, capsule, dispersing tablets, soft capsule, chewing tablets, buccal tablets, droplet, and other oral preparations according to the method in this invention.

Description

technical field [0001] The invention relates to a pharmaceutical composition with hydrochlorothiazide and benazepril hydrochloride as active components, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] With the improvement of people's living standards and changes in dietary structure and lifestyle, the incidence of hypertension has gradually increased in recent years. Hypertension can cause damage to the heart, brain, kidney and other organs of the patient, and is closely related to sugar and lipid metabolism disorders and diabetes, which can significantly reduce the quality of life of the patient, and even endanger life in severe cases. Therefore, the research on the pathogenesis and therapeutic drugs of hypertension has attracted more and more attention from scholars at home and abroad. [0003] Benazepril hydrochloride can inhibit the activity of angiotensin-converting enzyme, reduce the level of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/549A61K31/55A61K9/20A61K9/48A61P9/12
Inventor 李胜飞
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products