Pharmaceutical composition using hydrochlorothiazide and benazepril hydrochloride as active ingredients, its preparation method and use
A technology of benazepril hydrochloride and hydrochlorothiazide, which is applied in the field of medicine and can solve problems such as the incomplete understanding of the mechanism of action
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Embodiment 1
[0013] Embodiment 1 hydrochlorothiazide and benazepril hydrochloride tablet
[0014] components
Dosage
CMS-Na
Micropowder silica gel
95% ethanol
12.5g
10g
60g
25g
30g
4g
4g
2.5g
Appropriate amount
Co-made
1000 pieces
[0015] Preparation:
[0016] Pass hydrochlorothiazide, benazepril hydrochloride, microcrystalline cellulose, pregelatinized starch, and lactose through 80-mesh sieve respectively, after mixing evenly, add 95% ethanol to make soft material, granulate with 20-mesh sieve, dry, and 18-mesh sieve For granulation, add magnesium stearate, CMS-Na, and micropowder silica gel, mix well, and press a suitable die to form a tablet.
Embodiment 2
[0017] Embodiment 2: hydrochlorothiazide and benazepril hydrochloride capsules
[0018] components
Dosage
CMS-Na
2% PVP-k30 aqueous solution
12.5g
10g
20g
60g
2.0g
Appropriate amount
1.5g
[0019] Preparation:
[0020] Pass hydrochlorothiazide, benazepril hydrochloride, dextrin, and starch through 80-mesh sieve respectively, and after mixing evenly, add 0.5% PVP-k30 aqueous solution to make soft material, granulate with 24-mesh sieve, dry, granulate with 24-mesh sieve, add The prescribed amount of CMS-Na and magnesium stearate is mixed evenly and packed into suitable capsule shells.
Embodiment 3
[0021] Embodiment 3: hydrochlorothiazide and benazepril hydrochloride dispersible tablet
[0022] components
Dosage
CMS-Na
50% ethanol solution
Co-made
12.5g
10g
80g
40g
9g
Appropriate amount
1000 pieces
[0023] Preparation:
[0024] Pass hydrochlorothiazide, benazepril hydrochloride, microcrystalline cellulose, and lactose through 80-mesh sieve respectively, mix well, add 50% ethanol solution to make soft material, granulate with 24-mesh sieve, dry, granulate with 20-mesh sieve, add The disintegrating agent CMS-Na, after mixing evenly, compressing the tablet, that is to say.
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