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Celastrus orbiculatus ready prepared Chinese medicine and its application in resisting rheumatoid disease

A technology of Radix vulgaris and Chinese patent medicine, which is applied in the application field of anti-rheumatoid arthritis, can solve the problems of unclear active ingredients, incapable of large-scale production, insufficient action strength, etc., achieves good resistance to rheumatoid arthritis, reduces The effect of dosage and low cost

Inactive Publication Date: 2006-08-30
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, these pharmacological effects researches and clinical applications of S. chinensis all use the traditional water decoction or ethanol crude extract of S. sagera. Not only the dosage is large, the active ingredients are not clear, but also the side effects are relatively large, and the action strength is not enough. Unsatisfactory curative effect
Although there are also studies on the pharmacological effects of the monomeric components of S. chinensis, they cannot be produced on a large scale due to the low content and difficulty in separation.
There are no reports about extracting and refining the effective parts of S. sulphide, and rationally developing and utilizing S. S. sulphide extracts, especially extracts containing S. S. terpenoids.

Method used

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  • Celastrus orbiculatus ready prepared Chinese medicine and its application in resisting rheumatoid disease
  • Celastrus orbiculatus ready prepared Chinese medicine and its application in resisting rheumatoid disease
  • Celastrus orbiculatus ready prepared Chinese medicine and its application in resisting rheumatoid disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Get 10kg of S. chinensis medicinal material, add 95% ethanol 80kg, reflux extraction for 1 hour, filter, and the filtrate is for subsequent use, add 95% ethanol 70kg to the dregs, reflux extraction for 1 hour, filter, combine the filtrate twice, and combine the combined The filtrate is concentrated into a dilute extract with a relative density of 1.08, and the dilute extract is passed through the AB-8 macroporous adsorption resin, and first eluted to colorless with 30% ethanol, and the 30% ethanol eluate is discarded, and then used 95% ethanol elutes to colorless, collects this 95% ethanol eluate, concentrates the 95% ethanol eluate after recovering ethanol into a thick extract with a relative density of 1.11, sprays and dries this thick extract to obtain Total terpenoids 65% (more than 21% of total triterpenoids, 44% of total sesquiterpenoids) S. terpenoids extract.

Embodiment 2

[0031] Get 10kg of S. chinensis medicinal material, add 85% ethanol 90kg, reflux extraction for 2 hours, filter, and the filtrate is for subsequent use, add 85% ethanol 90kg to the dregs, reflux extraction for 1 hour, filter, combine the filtrate twice, and combine the combined The filtrate was concentrated to a relative density of 1.05, and the dilute extract was passed through AB-8 macroporous adsorption resin, first eluted to colorless with 20% ethanol, discarded the water eluent, and then eluted with 90% ethanol to Colorless, collect this 90% ethanol eluate, concentrate the 90% ethanol eluate after recovering ethanol into a thick extract with a relative density of 1.10, dry the thick extract under reduced pressure, add 5 times the amount of water, Heating makes dissolving, then adds n-butanol and extracts 3 times, each time n-butanol consumption is equal to the amount of water, combines the extracts, the combined extracts are reclaimed after n-butanols and dried to obtain 5...

Embodiment 3

[0033] Take 10kg of S. chinensis medicinal material, add 100kg of 70% ethanol and boil for 2 hours, filter, and the filtrate is set aside, add 90kg of 70% ethanol to the dregs, boil for 1 hour, filter, filter, combine the second filtrate, and combine After the filtrate was concentrated to a thin extract with a relative density of 1.05, the thin extract was passed through Diaion HP20 macroporous adsorption resin, and first eluted to colorless with 10% ethanol, and the 10% ethanol eluent was discarded, and then Elute with 70% ethanol until it is colorless, collect the 70% ethanol eluate, concentrate the 70% ethanol eluate after recovering ethanol into a thick extract with a relative density of 1.09, dry the thick extract under reduced pressure, Obtain the S. terpenoid extract containing 55% of total terpenoids (more than 17% of total triterpenes and 38% of total sesquiterpenes).

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Abstract

A Chinese patent medicine for treating rheumatoid arthritis, relieving inflammation and relaxing pain is prepared from oriental bittersweet stem through extracting and separating.

Description

technical field [0001] The present invention relates to a kind of Chinese patent medicine, more specifically, the present invention relates to a kind of Chinese patent medicine extracted from snake vine and its application in anti-rheumatoid arthritis. Background technique [0002] Snakevine is a plant of the genus Snakevine in the family Euonymus, also known as Guoshanfeng, Huangteng, Bitterbark, etc. The medicinal parts are its roots and canes. It is mainly distributed in Northeast my country, North China, East China, Northwest China, Southwest China, Guangdong and the two lakes regions of China. It is also distributed in Korea and Japan. Since the first report in 1949 that flavonoid glycosides were extracted and isolated from the leaves of S. serpentine, more than 40 components have been isolated from S. serpentine seeds, root bark, leaves and aerial parts. The main active ingredient is sesquiterpene , triterpenes, flavonoids and other ingredients. Traditional Chinese ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K9/107A61K9/16A61K9/20A61K9/22A61K9/48A61P29/00A61P19/02A61P37/02A61K135/00
Inventor 佟丽佘风华
Owner SOUTHERN MEDICAL UNIVERSITY
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