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Zhangyanming capsule and preparing process

A technology for capsule preparation and blindness, which is applied in the directions of capsule delivery, medical preparations containing active ingredients, and plant raw materials, etc., can solve the problems of unsightly appearance, slow dissolution rate of active ingredients, cumbersome coating process of sugar-coated tablets, etc.

Active Publication Date: 2006-08-09
湖南天济草堂制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the original drug belongs to the tablet Chinese medicine extract, which has a long disintegration time limit, slow dissolution rate of active ingredients, and is generally a sugar-coated tablet, which is not conducive to taking by some patients with sugar-avoiding diseases, especially diabetics and obese patients. People who take it are subject to certain restrictions. limit
The coating process of sugar-coated tablets is cumbersome, the appearance is not beautiful, and it is prone to mildew, which is not conducive to long-term storage. Obviously, it cannot meet the needs of doctors and patients in actual treatment.
In addition, the original process does not explain the important amount of water added in the extraction process, how to optimize the process of the present invention, how to complete the molding process if the dosage form is changed, and whether the improved process is suitable for large-scale industrial production. For Chinese medicine workers, it is unknown

Method used

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  • Zhangyanming capsule and preparing process
  • Zhangyanming capsule and preparing process
  • Zhangyanming capsule and preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] The active ingredients of the present invention are: Acorus calamus 22.8g, Cassia seeds 30.6g, Cistanche cistanche 37.8g, Pueraria lobata root 37.8g, Celosia argentea 30.6g, Codonopsis pilosula 48.6g, Vinegrass 30.6g, Chinese wolfberry 48.6g, Plantago seed 37.8g , Radix Paeoniae Alba 45.6g, Dogwood 24.6g, Licorice 22.8g, Cuscuta Seed 61.2g, Cimicifuga 7.8g, Endocarp 37.8g, Chrysanthemum 37.8g, Dense Mongolian Flower 37.8g, Chuanxiong 30.6g, Polygonatum 37.8g, Rehmannia glutinosa 61.2g, Phellodendron amurense 30.6g, Astragalus 48.6g.

[0070] The above twenty-two flavors, cassia seeds, vine seeds, dodder seeds, green argentea, and plantain seeds are soaked in boiling water for 20 hours, then add the remaining Shichangpu 17 flavors and boil twice, each time for 2 hours, each time adding 8 Double the amount of water, filter, combine the filtrate, concentrate to a clear paste with a relative density of 1.35 measured at 60℃, vacuum dry at 60℃-70℃, vacuum degree 0.07-0.08Mpa, cru...

Embodiment 2-4

[0072] In order to verify and perfect the experimentally researched preparation process, in order to achieve the operability of production and the adaptability to the relevant equipment, we magnified the formulation prescription by 10 times to feed, and the best process and technical conditions obtained under laboratory conditions were studied. Carry out three batches of pilot studies and record in detail the key technological parameters. The quality inspection of three batches of pilot products was carried out, and the results are shown in Table 14.

[0073] Lot number

[0074] Quality

[0075] The above results show that the preparation process conditions of the Zhangyanming capsules are reasonable and feasible; the methods of extraction, concentration, drying and preparation are compatible with the scale-up production equipment; the quality of the prepared products is qualified and can be used for industrial production.

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Abstract

The invention is a Zhangyanming capsule and the preparing process thereof, using main materials: Grassleaf Sweetflag Rhizome 22.8g, Cassia Seed 30.6g, Desertliving Cistanche 37.8g, Kudzuvine Root 37.8g, Feather Cockscomb Seed 30.6g, Pilose Asiabell Root 48.6g, Simpleleaf Shrub Chastetree Fruit 30.6g, wolfberry fruit 48.6g, Plantain Seed 37.8g, White Paeony Root 45.6g, Common Macrocarpium Fruit 24.6g, Liquorice Root 22.8g, Chinese Dodder Seed 61.2g, Rhizoma Cimicifugae 7.8g, Hedge Prinsepia Nut without endocarp 37.8g, Flos Dendranthematis 37.8g, Pale Butterflybush Flower 37.8g, Szechuan Lovage Rhizome 30.6g, King Solomonseal Rhizome 37.8g, Prepared Rehmannia Root 61.2g, Amur Corktree Bark 30.6g and Membranous Milkvetch Root 48.6g and using starch as auxiliary material, where the weight ratio of dry plaster prepared of effective components to starch is (170-175):80. Its quality is more reliable and stable, dampproof. The preparing method is more perfect, more beneficial to fully retaining effective components and able to save cost.

Description

Technical field [0001] The present invention is a traditional Chinese medicine capsule used for treating ocular cataract and its preparation process. Background technique [0002] The current commonly used drugs in the treatment of cataracts include Shaoyanming tablets, which have good curative effects on cataract patients in the early and middle stages of treatment. However, the original medicine belongs to the tablet. The traditional Chinese medicine extract has a long disintegration time, and the dissolution rate of the active ingredients is slow. Generally, sugar-coated tablets are not conducive to the consumption of certain diabetes patients, especially diabetic patients and obese patients. limit. The sugar-coated tablet coating process is cumbersome, the appearance is not beautiful, and it is prone to mildew, which is not conducive to long-term storage, and obviously cannot meet the needs of doctors and patients in actual treatment. In addition, the original process did not...

Claims

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Application Information

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IPC IPC(8): A61K36/882A61K9/48A61P27/12
Inventor 翁小涛
Owner 湖南天济草堂制药股份有限公司
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