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Chinese traditional medicine composition for promoting immunity and preparation and quality controlling method thereof

A quality control method and composition technology, which can be used in drug combinations, testing drug preparations, and pharmaceutical formulations, etc., can solve problems such as side effects, and achieve the effects of stable preparations and controllable quality.

Active Publication Date: 2006-06-21
安邦制药(哈尔滨)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Treatment should focus on enhancing physical fitness and improving disease resistance; in this period, antibacterial drugs with a broad antibacterial spectrum can be used for preventive treatment, but long-term use of antibacterial drugs is likely to cause side effects

Method used

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  • Chinese traditional medicine composition for promoting immunity and preparation and quality controlling method thereof
  • Chinese traditional medicine composition for promoting immunity and preparation and quality controlling method thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0038] Experimental example 1: Extraction process test

[0039] According to the traditional decoction method of the decoction, decoct the herbal flavor together with boiling water twice, each time for 1 hour, and use the method of centrifugation and standing to remove water-insoluble impurities. Select three factors such as decoction time, decoction frequency and decoction water consumption, select three levels of each factor, select 0.75-1.5 hours for decoction time, select 1-3 times for decoction times, select 5-3 times through pre-test 8 times the amount of water added is more appropriate. See Table 1 for factor levels.

[0040]

[0041] The three factors were arranged in the L9(34) orthogonal table, and the variance analysis was carried out. The index of investigation was the water extract determined by the drying method. The yield results are shown in Table 2 and Table 3.

[0042] Table 2 Orthogonal Design Table L9(34)

[0043]

[0044] source of...

experiment example 2

[0049] Experimental Example 2: Examination of the drying temperature of the extract and auxiliary materials (see Table 6)

[0050] temperature(℃)

[0051] Experiments show that the content does not change much when the drying temperature is 60°C and 80°C, and it is advisable to choose a lower drying temperature of 60°C based on other factors.

experiment example 3

[0052] Experimental Example 3: Content Determination Test

[0053] Take 10g of the sample, weigh it accurately, place it in a Soxhlet extractor, add 80ml of methanol to reflux and extract until the extract is colorless, recover the methanol from the extract and concentrate it to dryness, add 10ml of water to the residue, dissolve it with slight heat, and use water-saturated n-butane Alcohol shaking extraction 3 times, 15ml each time, combined n-butanol extract. Recover the solvent under reduced pressure, add 25ml of water to the residue to dissolve in stages (10, 5, 5, 5), pass through the D101 macroporous resin column (inner diameter 1.5cm, length 10cm) successively, add 20ml of 0.5mol / L sodium hydroxide solution to wash, Rinse with water until neutral, then elute with 50ml of 40% ethanol, discard the 40% ethanol eluate, and finally elute with 80ml of 70% ethanol, collect the eluate, evaporate to dryness, dissolve the residue in methanol and transfer to 1ml In the volumetric...

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PUM

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Abstract

The present invention discloses one kind of Chinese medicine composition for raising body's immunity and its preparation process and quality control method. The Chinese medicine composition is prepared with astragalus root, manyprickle acanthopanax root extractum, white atractylodes rhizome, schisandra, ledebouriella root and ophiopogon root. It possesses functions of benefiting Qi, consolidating superficial resistance, invigorating spleen and lung, and benefiting kidney; and is used in treating hypoimmunity caused by insufficiency of lung, spleen and kidney. The Chinese medicine composition of the present invention has high stability, determined curative effect and controllable quality.

Description

field of invention [0001] The invention relates to a traditional Chinese medicine composition, a preparation method and a quality control method thereof, in particular to a traditional Chinese medicine composition for improving body immunity, a preparation method and a quality control method thereof. Background technique [0002] Traditional Chinese medicine believes that the deficiency of the lung, spleen and kidney can cause chronic bronchitis and repeated colds, and the symptoms of patients with chronic bronchitis in the clinical remission period are relieved, but the pathological changes have not been eliminated. Treatment should focus on strengthening physical fitness and improving disease resistance; in this period, antibacterial drugs with a broad antibacterial spectrum can be used for proper preventive treatment, but long-term use of antibacterial drugs is likely to cause side effects. The use of traditional Chinese medicine treatment and immunomodulators to carry ou...

Claims

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Application Information

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IPC IPC(8): A61K36/8965A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P37/04G01N30/90G01N33/15
Inventor 王伟明张洪娟
Owner 安邦制药(哈尔滨)有限公司
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