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Novel drug administering route of pantocrine injection, its preparation process and novel indications

A technology of fine injection and injection, which is applied in the field of traditional Chinese medicine preparation deer antler essence injection, which can solve problems such as swelling, pain, injection induration, and small dosage

Inactive Publication Date: 2006-05-10
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in terms of clinical application, velvet antler injection adopts intramuscular injection method, which is absorbed through the tissue at a slower rate and with a smaller dose, which not only increases the pain of the patient, but also causes local induration, even swelling and pain, and secondary infection. Frequent injections can also easily lead to "gluteal muscle contracture"
This medication method obviously limits its clinical application
Therefore, in response to this problem, we have developed an intravenous route of administration, which overcomes the shortcomings of slow absorption and long onset time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The preparation method of injection of the present invention:

[0056] Prescription: deer antler 100g cresol 3g

[0057] Add water for injection to 1000ml

[0058] Preparation:

[0059] Take velvet antler (peeled and haired), slice or crush it into coarse powder, add 5 times the amount of 50% ethanol, reflux extraction four times, each time for 4 hours, combine the extracts, recover ethanol, concentrate under reduced pressure to obtain a liquid extract, Add 5 times the amount of 80% ethanol, stir well, let it stand for more than 12 hours, filter, wash the precipitate with 80% ethanol, combine the washing liquid with the filtrate, recover the ethanol, concentrate under reduced pressure until every 1g of the concentrated solution contains 2g of the original medicinal material , add 7 times the amount of ethanol, stir well, let it stand for 12 hours, filter, wash the precipitate with ethanol, combine the lotion with the filtrate, recover the ethanol and concentrate...

Embodiment 2

[0061] The preparation method of freeze-dried powder injection of the present invention:

[0062] Prescription: deer antler 300g cresol 3g dextran-40 70g

[0063] Add water for injection to 1000ml

[0064] Preparation:

[0065] Take velvet antler (peeled and haired), slice or crush it into coarse powder, add 5 times the amount of 50% ethanol, reflux extraction four times, each time for 4 hours, combine the extracts, recover ethanol, concentrate under reduced pressure to obtain a liquid extract, Add 5 times the amount of 80% ethanol, stir well, let it stand for more than 12 hours, filter, wash the precipitate with 80% ethanol, combine the washing liquid with the filtrate, recover the ethanol, concentrate under reduced pressure until every 1g of the concentrated solution contains 4g of the original medicinal material , add 7 times the amount of ethanol, stir fully, let stand for 12 hours, filter, wash the precipitate with ethanol, combine the lotion with the filtrate, re...

Embodiment 3

[0067] The preparation method of sterile powder of the present invention:

[0068] Prescription: deer antler 400g cresol 3g mannitol 200g

[0069] Makes 1000 bottles

[0070] Preparation:

[0071] Take velvet antler (peeled and haired), slice or crush it into coarse powder, add 5 times the amount of 50% ethanol, reflux extraction four times, each time for 4 hours, combine the extracts, recover ethanol, concentrate under reduced pressure to obtain a liquid extract, Add 5 times the amount of 80% ethanol, stir well, let it stand for more than 12 hours, filter, wash the precipitate with 80% ethanol, combine the washing liquid with the filtrate, recover the ethanol, and concentrate under reduced pressure until every 1g of the concentrated solution contains 5g of the original medicinal material , add 7 times the amount of ethanol, stir well, let it stand for 12 hours, filter, wash the precipitate with ethanol, combine the lotion with the filtrate, recover the ethanol and con...

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Abstract

The invention provides the novel route of administration and preparing process for Chinese medicinal injection for treating nervous prostration, loss of appetite, undernourishment, coronary disease, angina pectoris and arrhythmia. The injection is prepared from sika deer horns as the raw material, and can be made into the dosage forms of concentrated solution for injection, freeze-dried powder, germ-free powder, 5% glucose injection, and 9% sodium chloride injection.

Description

Technical field: [0001] The invention relates to a new administration route, a preparation process and a new indication of the traditional Chinese medicine preparation deer antler essence injection. technical background: [0002] Deer antler essence is a liquid preparation made from the ethanol extract of sika deer antler, which has the function of enhancing body vitality and promoting cell metabolism. A number of studies have shown that: velvet antler water extract has the effect of inhibiting the activity of MAO in the elderly, can promote the synthesis of RNA and protein, can enhance the activity of superoxide dismutase (SOD), reduce the content of malondialdehyde (MDA), and has anti-aging effects effect. Antler essence can also improve glycolysis and energy metabolism of the tridose acid cycle, increase coronary blood flow, enhance myocardial contractility, increase cardiac output, eliminate myocardial fatigue, and thus achieve a cardiotonic effect. Therefore, velvet a...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K35/32A61P7/06A61P9/06A61P9/10A61P25/00
Inventor 刘露
Owner FUKANGREN BIO PHARMA
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