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Traumatism-free type method for establishing animal model of limb deep vein thrombogenesis

A technology of deep vein thrombosis and animal models, applied in the field of medical models, can solve problems such as damaged blood vessels, and achieve the effects of high incidence, simple and easy production process, and low animal mortality

Inactive Publication Date: 2006-03-29
昆明医学院第一附属医院
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Problems solved by technology

[0006] Although the above modeling methods have their own characteristics, they are mainly used to study changes in blood coagulation and fibrinolytic systems, as well as related drug screening and curative effect evaluation, which are not consistent with the actual natural course of clinical DVT in orthopedics: (1) Absolute clinical DVT in orthopedics Most of them are subacute or chronic, and the thrombus formed by the above methods are all acute; (2), orthopedic clinical DVT hardly directly damages deep veins, and the above methods all directly damage blood vessels
(3) Most of the orthopedic clinical DVT occurs in patients with immobilized limbs after trauma or surgery and long-term bed rest. DVT occurs despite anticoagulants

Method used

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Embodiment Construction

[0043] 1. Modeling process and observation indicators

[0044] 1. Animals and groups

[0045] Healthy adult New Zealand white rabbits, weighing 3.0±0.2kg, male or female. Single-cage feeding, adaptive feeding for two weeks, during the feeding period, the rabbits were given pelleted feed, free to drink water, the room temperature of the rabbit house was 20°C, the relative humidity was 60% RH, and the ventilation was good. 120 New Zealand white rabbits were randomly divided into four groups: A, B, C, and D: Group A was the left hind limb fracture fixation group, B group was the left hind limb trauma and no fracture fixation group, and C group was the left hind limb no trauma fixation group. Group D was a blank control group without trauma or fixation. There are 30 animals in each group, and they are randomly divided into 3 groups according to different observation time points after modeling, with 10 animals in each group. The first group is the observation group 5 days after m...

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Abstract

A method for creating the animal model of the thrombosis in deep vein of limb without wound includes such steps as reforming the intramedullary nail driving-pulling tool to obtain a quantitative beater, and simulating the surgical wounding procedure to generate different wounds on lower limb of rabbit, resulting in thrombosis in deep vein. Its advantages are simple method and low dead rate.

Description

technical field [0001] The invention relates to the technical field of medical models, and is a method for establishing an animal model of traumatic limb deep vein thrombosis with orthopedic clinical characteristics, which can be used to study the occurrence, development and outcome of traumatic limb deep vein thrombosis and pulmonary thromboembolism, and explore more effectively The method of prevention, diagnosis and treatment provides an animal model platform. Background technique [0002] Thrombosis is a kind of disease that seriously endangers human health and life. It is found in patients in many clinical departments. Its morbidity, disability and mortality are very high, and it is extremely harmful. In western countries, the incidence rate of venous thromboembolism (VTE) is as high as 0.1%, and half of them are deep venous thrombosis (DVT). In the United States, there are about 650,000 hospitalizations and 50,000-200,000 deaths each year due to DVT and pulmonary thro...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 赵学凌李文黄河王兵赵宏斌何飞王建伟吴雪梅张春强贾代良赵智唐锡章周兆文李世和
Owner 昆明医学院第一附属医院
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