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Radix scutellariae total flavone extract and use of Radix scutellaride glucoside in preparing medicine for treating osteoporosis

A technology for the total flavonoids of Scutellaria baicalensis and osteoporosis, which is applied in the field of preparation of medicines for the treatment and/or prevention of osteoporosis of the total flavonoids of Scutellaria baicalensis extract and baicalin, and can solve the problems of no anti-osteoporosis and the like

Active Publication Date: 2006-03-08
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] In summary, Scutellaria baicalensis and its flavonoids have a wide range of pharmacological effects, but there is no anti-osteoporosis and related reports in the relevant literature at home and abroad.

Method used

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  • Radix scutellariae total flavone extract and use of Radix scutellaride glucoside in preparing medicine for treating osteoporosis
  • Radix scutellariae total flavone extract and use of Radix scutellaride glucoside in preparing medicine for treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Effect of Baicalin and Scutellaria Radix Total Flavonoids Extract on Rat Osteoblast Growth and Differentiation

[0040] 1. Test material

[0041] (1) Test drug

[0042] Test samples: baicalin (greater than 95%, HPLC method), Scutellaria baicalensis total flavonoids extract I (content 70%, uv method, macroporous resin preparation method), Scutellaria baicalensis total flavonoids extract II (content 50%, uv method, Acid-base preparation method), Scutellaria baicalensis total flavonoids extract III (content 30%, uv method, ethanol extraction), Scutellaria baicalensis total flavonoids extract IV (content 25%, uv method, water extraction).

[0043] Properties: light yellow powder, slightly gas, bitter taste

[0044] Storage conditions: dark, airtight

[0045] Preparation method: weigh a certain amount of drug to be tested, and prepare a suspension with 1% sodium carboxymethylcellulose solution.

[0046] (2) animals

[0047] Strain: SD rat

[0048] Source: Sha...

Embodiment 2

[0088] Example 2 Effect of baicalin and total flavonoids extract of Scutellaria baicalensis on osteoclast function in neonatal rats

[0089] 1. Test material

[0090] (1) Test drug

[0091] Test samples: baicalin (more than 95%, HPLC method), total flavonoids extract of Scutellaria baicalensis (more than 70%, uv method, macroporous resin preparation method), total flavonoids extract of Scutellaria baicalensis II (content 50%, uv method, acid Alkali preparation method), total flavonoids extract of Scutellaria baicalensis III (content 30%, uv method, ethanol extraction), Scutellaria baicalensis total flavonoids extract IV (content 25%, uv method, water extraction).

[0092] Properties: light yellow powder, slightly gas, bitter taste

[0093] Storage conditions: dark, airtight

[0094] Preparation method: weigh a certain amount of drug to be tested, and make a suspension with 1% sodium carboxymethylcellulose solution

[0095] (2) animals

[0096] Strain: SD rat

[0097] Sou...

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PUM

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Abstract

The present invention relates to application of scutellaria total flavone extract and baicalin in preparation of medicine for curing and / or preventing osteoporosis. The baicalin is 5,6-dihydroxyflavone-7-0-glucoglycuronide, and the scutellaria total flavone extract includes baicalin, baicalein, wogonin, wogonoside and neobaicalein, etc. as its main effective components.

Description

technical field [0001] The invention relates to a medicine for treating and / or preventing osteoporosis, in particular to the use of total flavonoids extract from Scutellaria baicalensis and baicalin in the preparation of medicines for treating and / or preventing osteoporosis. Background technique [0002] Osteoporosis (sometimes referred to as osteoporosis for short) is a skeletal disease in which the bone components of the whole body are reduced. After menopause), the microstructure of bone tissue changes and the normal load function of bone tissue changes. Osteoporosis is clinically manifested as low back pain, pathological fractures, vertebral body deformation, and postural deformation resulting in "turtle back", accompanied by symptoms such as pain in the bones of the whole body. [0003] Primary osteoporosis accounts for 90% of osteoporosis. It is a common disease in the elderly, a systemic bone disease. The main manifestations are the reduction of bone mineral and bo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P19/10
Inventor 严启新赵金华张丽娟
Owner SHENZHEN NEPTUNUS PHARM CO LTD
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