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Chinese medicine injection for clearing away heat and toxic matter and its prepn process

An injection preparation, heat-clearing and detoxifying technology, applied in antiviral agents, pharmaceutical formulations, drug delivery, etc., can solve the problems of failing to meet the quality requirements of traditional Chinese medicine injections, not fully exerting the efficacy of drugs, and poor stability of injections, etc., to achieve The curative effect is rapid and significant, the quality and stability are improved, and the quality is stable

Inactive Publication Date: 2006-03-01
张正生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The patent (application number 00114304.2) discloses a preparation method of a Chinese patent medicine for clearing heat, detoxifying and anti-infection. In this invention, honeysuckle, Folium Folium, Dandelion, and Houttuynia cordata are extracted and prepared into granules, which have the functions of clearing away heat, detoxifying and anti-infection, and have antibacterial properties. , anti-virus, anti-endotoxin, antipyretic, anti-inflammatory, immune regulation and other characteristics, it has a certain effect on wind-warm lung-heat syndrome such as cold, influenza and acute respiratory infection, but for acute infectious diseases, granules play a role The effect is slow and the bioavailability is low, so the efficacy of the prescription cannot be fully exerted; in the 1970s, someone prepared the four herbs of Lonicera vine, Folium Folium, Dandelion, and Houttuynia cordata into "Anti-inflammatory No. 6 Injection". Due to the relatively simple preparation process, the prepared injection has poor stability and cannot meet the relevant quality requirements of traditional Chinese medicine injections, so it did not become a formal marketed product in the end.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] (1) The composition by weight of the raw material medicine is: each 250g of honeysuckle, Folium Folium, Dandelion, and Houttuynia cordata;

[0075] (2) Get Houttuynia cordata, steam distill, collect the first distillate 1300ml, redistill again, collect the double distillate 250ml, save it separately, and set aside;

[0076] (3) Wash honeysuckle, Folium Folium, and dandelion, add water to decoct twice, 1 hour each time, combine the decoction, filter, concentrate under reduced pressure to about 200ml, put ribs, and use ethanol precipitation for three times, the first time The ethanol content in the solution is 60%, the second time is 80%, and the third time is 85%. Before each alcohol precipitation, the medicinal solution is concentrated to a relative density of 1.15-1.20 (50° C.), and after alcohol precipitation, it is below 15° C. Stand still for 48 hours, filter, and concentrate the filtrate after three times of alcohol precipitation to about 50ml under reduced pressur...

Embodiment 2

[0079] (1) The composition by weight of the raw material medicine is: each 250g of honeysuckle, Folium Folium, Dandelion, and Houttuynia cordata;

[0080] (2) Get Houttuynia cordata, steam distill, collect 1000ml of initial distillate, redistill again, collect 250ml of double distillate, save it separately, and set aside;

[0081] (3) Wash honeysuckle, Daqingye, and dandelion, add water to decoct 3 times, 1 hour each time, combine the decoction, filter, concentrate under reduced pressure to about 200ml, put ribs, and use ethanol precipitation for three times, the first time The ethanol content in the solution is 65%, the second time is 80%, and the third time is 90%. Before each alcohol precipitation, the medicinal solution is concentrated to a relative density of 1.15-1.20 (50° C.), and after alcohol precipitation, it is below 15° C. Stand still for 48 hours, filter, and concentrate the filtrate after three times of alcohol precipitation to about 50ml under reduced pressure, ...

Embodiment 3

[0084] (1) The composition by weight of the raw material medicine is: each 250g of honeysuckle, Folium Folium, Dandelion, and Houttuynia cordata;

[0085](2) Get Houttuynia cordata, steam distill, collect the first distillate 1500ml, redistill again, collect the double distillate 250ml, save it separately, and set aside;

[0086] (3) Wash honeysuckle, Folium Folium, and dandelion, add water to decoct twice, 1 hour each time, combine the decoction, filter, concentrate under reduced pressure to about 200ml, put ribs, and use ethanol precipitation for three times, the first time The ethanol content in the solution is 60%, the second time is 75%, and the third time is 85%. Before each alcohol precipitation, the medicinal solution is concentrated to a relative density of 1.15-1.20 (50° C.), and after alcohol precipitation, it is below 15° C. Stand still for 24 hours, filter, and concentrate the filtrate after three times of alcohol precipitation to about 50ml under reduced pressure...

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Abstract

The Chinese medicine injection for clearing away heat and toxic material is prepared with honeysuckle, isatis leaf, dandelion and cordate houttuynia in the same proportion as material and through extractive, purification and other steps. The injection has high quality, high stability and high pharmaceutical effect.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of a heat-clearing and detoxifying traditional Chinese medicine injection preparation and the preparation thereof. Background technique [0002] The proportion of infectious diseases in clinical practice is very high. At present, the western medicine method of clinical treatment is mainly the application of antibacterial drugs. Due to the increase of adverse reactions caused by antibacterial drugs and the emergence of drug-resistant strains, the course of disease will be prolonged and the treatment will be ineffective in clinical treatment. And other issues. The anti-infection mechanism of traditional Chinese medicine is not directly antibacterial and bactericidal, but mainly to increase the phagocytosis index of neutrophils in blood and the level of total complement in serum, thereby enhancing the body's non-specific...

Claims

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Application Information

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IPC IPC(8): A61K36/855A61K36/78A61K36/288A61K36/355A61K9/08A61P31/04A61P31/16A61P11/00
Inventor 张正生
Owner 张正生
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