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High purity cnidicin and its preparation method and medicinal composition using said compound as active component

A kind of osthole, high-purity technology, applied in the direction of drug combination, organic active ingredients, medical preparations containing active ingredients, etc., to achieve the effect of good reproducibility

Inactive Publication Date: 2006-01-25
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unable to make osthole clinically available as a single-component drug
At present, no country has researched and developed it as a drug and put it on the market

Method used

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  • High purity cnidicin and its preparation method and medicinal composition using said compound as active component
  • High purity cnidicin and its preparation method and medicinal composition using said compound as active component
  • High purity cnidicin and its preparation method and medicinal composition using said compound as active component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] (1) Add 500-800 ml of 80% ethanol to 100 g of Cnidium chinensis medicinal material, and reflux for extraction for 3 times, and reflux for 1 hour each time. The combined ethanol solution was rotary evaporated, and the ethanol was reclaimed at 65 ° C. The residual water turbid solution was 220 ml and the macroporous adsorption resin was used to live. The effective column length was 43 cm, and the column diameter was 6 cm (NKA-12). discarded). Then, it was eluted with 1500 ml of 40% ethanol to obtain a brown eluate, and HPLC showed that it did not contain osthole (obtained II). The coumarin component mainly osthole was obtained by eluting with 75% ethanol (obtaining III). The resin column was regenerated by eluting the adsorbed pigment with acetone. Part III recovered the solvent and dried it in an oven at 60°C to obtain a light yellow solid substance. The content of osthole was more than 60% as detected by HPLC. It was separated with a macroporous resin column, and 120g...

Embodiment 2

[0141] Take 50.0 g of osthole, 50.0 g of medicinal starch, and an appropriate amount of 50% ethanol, granulate, granulate, dry, and pack 2# capsules, each containing 0.1 g of osthole.

Embodiment 3

[0143] Take 50.0g of osthole, 30.0g of medicinal starch, 30.0g of dextrin, and an appropriate amount of 50% ethanol, fully stir and mix the above-mentioned raw materials to make granules, dry at 60-70°C for 2-4 hours, and make 1000 tablets, each The tablet contains 0.05g of osthole.

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Abstract

The invention discloses a high- purity of osthol, structure proof with spectral analysis, method for preparation, stability study, acute toxicity study, the drug compositions containing osthol, and new drug utilities of the natural product. By the technique steps of extracted Chinese pharmacy conidium fruit with alcohol, decolorizing and enriching by large-hole adsorption resin, and separating and purifying, it can prepare osthol with a purity of above 98%. The study expresses that the osthol has a clear utility of anti-cancer, anti-auto lymphoma, and so on.

Description

Technical field: [0001] The extraction and separation technology of the high-purity osthole of the invention belongs to the preparation technology of natural drug monomer components in the field of medicine. In particular, it involves the extraction and separation of high-purity osthole, and the application of osthole in the preparation of drugs for preventing and treating tumors, tumor radiation sensitization, and increasing white blood cells. Background technique: [0002] The macroporous adsorption resin method is a new technology developed in the 1970s. Due to its advantages of rapidity, high efficiency, convenience, sensitivity, and good selectivity, it has been used in the extraction and separation of active ingredients of traditional Chinese medicines and traditional Chinese medicine preparations in recent years. Widely used in quality control and analysis. The macroporous resin adsorption technology can shorten the production cycle, and the required equipment is sim...

Claims

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Application Information

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IPC IPC(8): C07D311/20A61K31/366A61K9/00A61P35/00
Inventor 周则卫沈秀刘培勋
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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