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Injection for treating cardiovascular and cerebrovascular diseases, and its prepn. method

A technology of cardiovascular and cerebrovascular injections, which is applied in the field of traditional Chinese medicine, can solve the problems of ineffective development of cardiovascular and cerebrovascular effects, and achieve the effects of broadening uses, convenient transportation, and long shelf life

Inactive Publication Date: 2006-01-25
孙毅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Motherwort mainly contains alkaloids, flavonoids, diterpenoids, volatile oils and other compounds. Pharmacological studies have proved that it has the functions of regulating menstruation and hemostasis, protecting myocardial ischemia-reperfusion injury, anti-platelet aggregation, and reducing blood viscosity. Only its gynecological effects are used, and its cardiovascular and cerebrovascular effects have not been effectively developed, and motherwort is compatible with one or more of medicines such as astragalus, notoginseng, and leeches to strengthen its curative effect of promoting blood circulation and removing blood stasis, and can also reduce blood stasis. Effectively protect brain cells

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 of the present invention: Take 1000g of motherwort, add water and decoc three times, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a clear cream with a relative density of 1.25 to 1.35, and then settle with 80% to 95% ethanol and alcohol. Set, filter, and recover ethanol as the motherwort extract. Take the motherwort extract, add 0.5% sodium bisulfite as an antioxidant, add water for injection to make 1ml containing 20mg-40mg of total alkaloids of motherwort, then add activated carbon (amount 0.01%~0.5%) for adsorption, coarse filtration Charcoal, fine filtration, potting, and sterilization are available immediately.

Embodiment 2

[0013] Example 2 of the present invention: Take 5g of motherwort total alkaloids, add 0.5% sodium bisulfite as antioxidant, add water for injection to make 1ml contains motherwort total alkaloids 20mg-40mg, adjust the PH value with a pH regulator 4.0 to 6.0, then add activated carbon (with a dosage of 0.01% to 0.5%) for adsorption, coarse filtration and decarbonization, fine filtration, potting, and sterilization to obtain.

Embodiment 3

[0014] Example 3 of the present invention: Take the motherwort extract or the total alkaloids of motherwort described in Examples 1 and 2, add 0.5% sodium bisulfite as an antioxidant, and then add 5% glucose or 0.9% sodium chloride As an isotonic regulator, add water for injection to make 1ml of total alkaloids of motherwort 0.20mg~0.40mg, adjust the pH to 4.0~6.0 with a pH regulator, and then add activated carbon (the dosage is 0.01%~0.5%) for adsorption, Coarse filtration and decarbonization, fine filtration, potting, sterilization, ready-to-use.

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PUM

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Abstract

A Chinese medicine in the form of injection for treating the ischemic cardiovascular and cerebrovascular diseases, such as cerebral infarction, cerebral thrombosis, apoplexy sequel, coronary heart disease and angina pectoris, is prepared from motherwort (5-95 wt%) and one or more of astragalus root, notoginseng and leech (5-95 wt%). Its preparing process is also disclosed.

Description

Technical field [0001] The invention is an injection for cardiovascular and cerebrovascular and a preparation method, belonging to the field of traditional Chinese medicine. Background technique [0002] With the aging of society and the improvement of living standards, the incidence and mortality of cardiovascular and cerebrovascular diseases are increasing. According to a recent study, surveys in 8 major regions of the world, including developed and developing countries, show that ischemic heart disease and cerebrovascular disease have become the main causes of death. For example, in the United States, cardiovascular disease far exceeds cancer, accounting for 42% of all deaths, becoming the main cause of death. In my country, cardiovascular and cerebrovascular diseases have also become one of the common and frequently-occurring diseases of the elderly, especially cerebrovascular diseases, with a prevalence rate of up to 491.8 per 100,000 people, which is significantly higher th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/533A61K9/08A61K9/19A61P9/00A61P9/10A61P7/02
Inventor 孙毅高红王晓玲张健
Owner 孙毅
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