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Solid tumor treating medicine composition

A composition and drug technology, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., and can solve problems such as systemic toxicity and side effects that limit clinical applications.

Inactive Publication Date: 2005-12-14
DASEN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the combination with other anticancer drugs has a certain effect on some tumors, the systemic side effects caused by conventional administration limit its clinical application

Method used

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  • Solid tumor treating medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Put 90 mg of polylactic acid (PLA) with a molecular weight of 10,000 as a pharmaceutical excipient into a container, add 100 ml of organic solvent dichloromethane to dissolve and mix, add 10 mg of melphalan, re-shake, and then vacuum dry to remove the organic solvent. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain a pharmaceutical composition for treating solid tumors containing 10% by weight of melphalan as a slow-release implant.

Embodiment 2

[0053] Embodiment two: as described in embodiment one, the difference is that the components are one of the following, all in weight percent:

[0054] (A) 5.15% melphalan and 85-95% polyglycolic acid and glycolic acid copolymer;

[0055] (B) 15-35% melphalan and 65-85% polyglycolic acid and glycolic acid copolymer;

[0056] (C)5 15% melphalan and 85-95% polylactic acid;

[0057] (D) 15-35% melphalan and 65-85% polylactic acid;

[0058] (E) 5-15% melphalan and 85-95% polyphenylene;

[0059] (F) 15-35% melphalan and 65-85% polyphenylene.

Embodiment 3

[0061] Put polylactic acid (PLA) with a molecular weight of 15,000 as a pharmaceutical excipient weighing 85 mg into a container, add 100 ml of organic solvent dichloromethane to dissolve and mix, add 15 mg of melphalan, re-shake, and vacuum dry to remove the organic solvent . The dried solid composition is shaped immediately, subpackaged and then sterilized by radiation to obtain a pharmaceutical composition for treating solid tumors containing 15% by weight of melphalan as a slow-release implant.

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Abstract

The present invention is solid tumor treating medicine composition and belongs to the field of medicine technology. The medicine composition contains melphalan in effective anticancer amount and medicinal supplementary material. The medicinal supplementary material is mainly biocompatible, degradable and absorbable polymer, and during the degradation and absorption of the polymer, melphalan is released slowly to local tumor part to lower the systemic toxic reaction and to maintain local medicine concentration. The present invention has enhanced treating effect. The solid tumor includes cerebral tumor, liver cancer, lung cancer, esophagus cancer, gastric cancer, etc.

Description

(1) Technical field [0001] The invention relates to a pharmaceutical composition for treating solid tumors, belonging to the technical field of medicines. (2) Background technology [0002] Although the research on cancer has made great progress, its mortality rate is still in the forefront of various common causes of death. In my country, about 1.6 million people suffer from cancer every year, and nearly 1.3 million people die of cancer, accounting for one-fifth of the total death toll. The incidence of cancer is increasing year by year and tends to be younger. Statistics show that in less than 20 years, the incidence of cancer in my country has increased by 69%, and the mortality rate has increased by 29.4%. According to the latest statistics from the World Health Organization, the global cancer incidence rate will increase by 50% by 2020, and the number of patients will increase to 15 million. Therefore, exploring an effective method or drug for treating cancer has beco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198
Inventor 孔庆忠
Owner DASEN BIOLOGICAL PHARMA CO LTD
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