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Epalorestat capsule, and its prepn. method

A technology of epalrestat and capsule, applied in the field of epalrestat capsule and its preparation, can solve the problems of poor fluidity, poor dissolution of epalrestat capsule, etc., and achieves good fluidity, low cost, Simple preparation process

Inactive Publication Date: 2005-11-09
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problems of poor dissolution rate and poor fluidity of epalrestat capsules

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1: 1000 epalrestat capsules were prepared with the following raw materials: 50 g of epalrestat, 30 g of lactose, 6 g of microcrystalline cellulose, 40 g of starch, 6 g of sodium starch glycolate, and 2 g of micropowdered silica gel. Its preparation method:

[0009] (1) Crush the raw and auxiliary materials through a 100-mesh sieve, weigh epalrestat, lactose, microcrystalline cellulose, starch, and carboxymethyl starch sodium according to the formula, and mix them evenly in a wet mixing granulator.

[0010] (2) Use 20% ethanol to make soft materials, 20 mesh sieves to make wet granules, dry them in a hot air circulation oven at 55°C to 65°C, and control the moisture content to be less than 3%.

[0011] (3) After 18-mesh sieve, the granules are finally mixed with the formula amount of micropowder silica gel, the granule content is measured, red capsules are packed, polished, and packaged.

Embodiment 2

[0012] Example 2: 1000 epalrestat capsules were prepared with the following raw materials: 50 g of epalrestat, 40 g of lactose, 5 g of microcrystalline cellulose, 30 g of starch, 7 g of sodium starch glycolate, and 3 g of micropowdered silica gel. The preparation method is the same as above.

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Abstract

A capsule of epalrestat is proportionally prepared from epalrestat, lactose, microcrystalline cellulose, starch, carboxymethyl starch sodium, and silica gel, micropowder through sequential mixing, adding alcohol, granulating, drying, adding silica gel micropowder, stirring and loading in capsules.

Description

technical field [0001] The invention relates to an epalrestat capsule and a preparation method thereof. Background technique [0002] The epalrestat raw material is hydrophobic, almost insoluble in water, and has poor fluidity. Contents of the invention [0003] In order to solve the problems of poor dissolution rate and poor fluidity of epalrestat capsules. The invention provides an epalrestat capsule and a preparation method thereof. [0004] An epalrestat capsule of the present invention, its raw material weight composition is: 15%-65% of epalrestat, 10%-80% of lactose, 10%-80% of microcrystalline cellulose, 10%-80% of starch, Carboxymethyl starch sodium 1% to 10%, micropowder silica gel 0.1% to 5%. [0005] The preparation method of the epalrestat capsule of the present invention is as follows: take and sieve epalrestat, starch, lactose, carboxymethyl starch sodium, and microcrystalline cellulose according to the weight composition of the raw materials, and mix them...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/425
Inventor 孙海胜陆小平陈娟余慧剑孙路进
Owner YANGTZE RIVER PHARM GRP CO LTD
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