Method for synthesizing organic sulfur compound under condition without solvent

Abstract

The present invention provides an environment-protecting type synthesis method for synthesizing organic sulfur compound under the solvent-free condition by using inodorous thioketenes compound as sulfur source reagent and adding organic acid or inorganic acid as catalyst so as to implement synthesis of series organic sulfur compounds.

Description

Technical field: [0001] The invention belongs to an organic synthesis method, and in particular relates to an environment-friendly synthesis method using a thioketene compound as a sulfur source reagent and synthesizing an organic sulfur compound under a solvent-free condition. Background technique: [0002] Organosulfur compounds, such as thioacetals / ketones, thioethers, thienes, etc., are commonly used chemical reagents in laboratories and synthetic precursors or intermediates in organic synthetic chemistry. At the same time, organosulfur compounds are important chemical raw materials, and have a very wide range of applications in the fields of medicine, pesticides, and spices. There are many ways to synthesize organosulfur compounds, such as the condensation reaction of mercaptans and aldehydes / ketones catalyzed by different acids (protonic acid, Lewis acid, solid acid, etc.), the addition reaction with unsaturated olefins, and the reaction with halogenated Alkylation re...

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Problems solved by technology

Low-molecular-weight mercaptans are often used in the reaction. This kind of thiol reagent is not only expensive, toxic, and inconvenient to transport, but also volatile, has an unbearable odor, and has a strong penetrating odor. It is easy to cause environmental pollution and damage users. health

With the increasing attention to environmental issues around the world, some researchers have begun to devote themselves to the non-toxic and odorless transformation of thiol reagents, such as increasing the length of the alkyl chain, introducing silyl groups on the aromatic ring, and thiols with high Molecularization, etc. (①Tetradedron Lett.2001, 42, 9207; ②J.Org.Chem.2000, 65, 4839.), but this kind of odorless thiol itself is mostly prepared by small molecule thiol or other toxic sulfur-containing reagents, That is, failure to solve the problem from the source

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