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Malus asiatica soft capsule and its preparation technology

A technology of soft capsules and bonuses, applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of difficult control of hygienic conditions, unacceptable by patients, and slow dissolution rate, etc., and achieve easy control of hygienic conditions, Accelerated dissolution and absorption, high bioavailability

Inactive Publication Date: 2005-10-26
GUANGXI HUAHONG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcomings are very significant, the difference in loading is unstable, and it cannot effectively cover up the unpleasant odor of the drug, etc.
In particular, the pharmaceutical excipients used are all inorganic fillers, which cannot be absorbed. For example, when filling in capsules, the excipients will also react with gelatin capsules, making the capsules not easy to dissolve, resulting in a decrease in dissolution rate and affecting the therapeutic effect.
At the same time, during the preparation process, the dust is large, and the hygienic conditions are difficult to control
And every time you need to take a large amount, it is difficult for patients to accept

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] API prescription:

[0035] 3334 grams of a little red, 2000 grams of Hedyotis diffusa, 3334 grams of Peach Blossom, 2000 grams of tung tree, 2000 grams of scorpion, 2666 grams of Mildew Spatholobus, and 3334 grams of myrtle root.

[0036] Preparation method of active ingredient:

[0037] Add a little red, Hedyotis diffusa, Peach Blossom, White-backed Tung, Lily, Millae Spatholobus, and Myrtle root to decoct twice, adding 10 times the amount of medicine for the first time, Decoct for 3 hours, the second time is 8 times the amount of medicine, decoct for 1.5 hours, filter, the filtrate is vacuum-dried and concentrated to a relative density of 1.20 (80°C), the vacuum drying temperature is 60°C, and the vacuum degree is 0.01Mpa , to obtain a clear paste, add ethanol until the content of ethanol is 65%, let it stand, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.28 (80°C), dry it in vacuum at 70°C, crush it to 120 ...

Embodiment 2

[0040] API prescription:

[0041] 1,500 grams of red, 4,000 grams of Hedyotis diffusa, 2,000 grams of Peach Blossom, 4,500 grams of Tungia chinensis, 4,500 grams of Spathiphyllum, 5,000 grams of Miltonia Spatholobus, and 4,000 grams of myrtle root.

[0042] The preparation method is the same as in Example 1.

[0043] Mix 500 grams of the extracted active ingredient, 280 grams of peanut oil and 50 grams of polyethylene glycol 6000, and divide them into soft capsules to obtain the product. Each soft capsule contains 0.54 grams of the drug, including 0.3 grams of the active ingredient.

Embodiment 3

[0045] Clinical Trial Results:

[0046] Clinical comparison: the soft capsule of embodiment 1 and Fukeqianjin Tablets were compared with each other, including 90 cases in the observation group of Example 1 and 90 cases in the Fukeqianjin Tablets control group).

[0047] Treatment method: "Example 1" treatment group: 2 capsules / time, 3 times / day (3.24g / day), continuous use for 21 days; Fuke Qianjin Tablets: 6 tablets / time, 3 times / tablet (5.76g / day) , used continuously for 21 days. During the treatment period, all Chinese and Western medicines with the same effect as the experimental medicine are prohibited. The test results are as follows:

[0048]1. The overall curative effect comparison of two groups: the total effective rate of embodiment 1 is 92.3%, and the total curative effect rate is 66.1%; 93.3%, the total effective rate was 42.2%. The total effective rate of Fuke Qianjin Tablets is 86.1%, and the total curative effect rate is 17.4%. The total effective rate of TCM...

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PUM

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Abstract

A Huahong softcapsule for treating morbid leukorrhea, menoxenia, menalgia, endomestritis, adnexitis, pelvic inflammation, etc is composed of the sac body and suspension filled in said sac body.

Description

technical field [0001] The invention relates to a Chinese patent medicine preparation for treating diseases such as women's chronic pelvic inflammatory disease and a preparation method thereof, in particular to a capsule. Background technique [0002] Pelvic inflammatory disease is a common disease in women, including inflammation of pelvic reproductive organs, such as uterine body, fallopian tubes, ovaries, etc., as well as pelvic peritoneum and connective tissue around the uterus. High incidence age of pelvic inflammatory disease. Seriously affected people's life and work. For this reason, many scientific and technical workers and relevant pharmaceutical manufacturers have disclosed their own medicines for the treatment of pelvic inflammatory disease, including traditional Chinese medicine preparations and chemically synthesized medicines. Obtained people's favor, such as the technology reported in Chinese Patent Publication No. CN1586519A and CN1552371A, commercialized ...

Claims

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Application Information

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Inventor 韦飞燕
Owner GUANGXI HUAHONG PHARMACEUTICAL CO LTD
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