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Prevention and treatment of functional somatic disorders, including stress-related disorders

A disorder and stress technology, applied in the prevention or treatment of functional physical diseases including stress-related disorders, and the prevention or treatment of stress-related diseases, which can solve the problem of no patient choosing the direction of therapy and no new drug development. offer, etc.

Inactive Publication Date: 2005-08-31
CYPRESS BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] The problem with all proposed models is that they provide no direction for patient selection of therapy, nor for new drug development, since no hypotheses to be tested arise from these explanations

Method used

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  • Prevention and treatment of functional somatic disorders, including stress-related disorders

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[0020] abbreviation

[0021] CFS Chronic Fatigue Syndrome

[0022] FMS fibromyalgia syndrome

[0023] PTSD Post Traumatic Stress Disorder

[0024] SRD stress-related disorder

[0025] FSD functional physical disorder

[0026] 5-HT serotonin

[0027] NE norepinephrine

[0028] NMDA N-methyl-D-aspartate receptor

[0029] NSAIDs nonsteroidal anti-inflammatory drugs

[0030] SSRIs selective serotonin reuptake inhibitors

[0031] TCAs tricyclic antidepressants

[0032] SNRIs dual serotonin / norepinephrine reuptake inhibitors

[0033] 5-HT>NE is implied.

[0034] Means 5-HT>NE

[0035] NSRI NE > 5-HT Alternative abbreviation for SNRI

[0036] DA dopamine

[0037] TRIs are compounds that block the reuptake of 5-HT, NE and DA.

[0038] DRIs are compounds that block the reuptake of 5-HT and NE. This class of compounds can be further subdivided into SNRI and NSRI subclasses.

[0039] definition

[0040] The term "dual serotonin / norepinephrine reuptake inhibitor compound"...

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Abstract

The present invention discloses a method of preventing or treating stress-related disorders to individuals under stress by administering an effective dose of a dual serotonin / norepinephrine reuptake inhibitor. A serotonin / norepinephrine / dopamine triple monoamine reuptake inhibitor may also be administered to persons at risk of developing a stress-related disorder. In a preferred embodiment, the compound is milnacipran and is administered prophylactically in an amount effective to delay or prevent stress-related disorders in at-risk patients.

Description

[0001] This application claims priority to British Patent U.S.S.N. 60 / 375,068, filed April 24, 2002, entitled "Methods of Treatment of Functional Physical Disorders," by Jay D. Kranzler and Srinivas G. Rao and filed April 18, 2003. Priority rights to a UK patent titled "Prevention and treatment of stress-related disorders" filed on 11 December 2019. field of invention [0002] The present invention relates to a method of preventing or treating functional somatic diseases (FSDs) including stress-related disorders (SRDs). In a particular aspect, the present invention relates to methods of treatment or prevention using dual serotonin and norepinephrine reuptake inhibitors having NMDA (N-methyl-D-aminoaspartic acid) antagonistic activity. In another aspect, the present invention relates to the treatment of at least one somatic symptom and one central nervous system symptom ( CNS) method. In a preferred embodiment, the present invention relates to the prevention or treatment of s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D333/20A61K31/135A61K31/137A61K31/165A61K31/195A61K31/198A61K31/38A61K31/381A61K31/485A61K31/496A61K31/55A61K31/551A61K31/5513A61K45/00A61K45/06A61P1/00A61P13/10A61P19/02A61P25/00A61P25/06A61P25/22A61P43/00
CPCA61K45/06A61K31/551A61K31/485A61K31/137A61K31/5513A61K31/38A61K31/165A61K31/198A61K31/496A61K31/135A61K31/195A61K31/55A61P1/00A61P1/04A61P13/10A61P15/08A61P19/00A61P19/02A61P21/00A61P25/00A61P25/04A61P25/06A61P25/18A61P25/20A61P25/22A61P25/24A61P29/00A61P43/00A61K2300/00
Inventor 斯利尼瓦斯·G·拉奥杰·D·克兰兹勒
Owner CYPRESS BIOSCI
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