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Model of endometriosis and modeling method

A technology of endometrium and establishment method, which is applied in the field of endometriosis model and model establishment, can solve problems such as limiting disease research, and achieve the effect of overcoming immune rejection, significant model traits, and high success rate

Inactive Publication Date: 2005-08-31
ANHUI PROVINCIAL HOSPITAL
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  • Description
  • Claims
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Problems solved by technology

[0004] The existence of the above reasons greatly limits the research on this disease

Method used

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  • Model of endometriosis and modeling method
  • Model of endometriosis and modeling method
  • Model of endometriosis and modeling method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] The endometriosis model of NOD-SCID mice in this example is a model of endometriosis in which human decidual tissues of early pregnancy were implanted subcutaneously in the abdomen of NOD-SCID mice to establish the endometriosis model.

[0025] The establishment of the model operates as follows:

[0026] Materials: The decidua was taken from a woman undergoing artificial abortion, 40-50 days pregnant, and the gynecological examination confirmed that there was no sign of threatened abortion, obvious villi were seen after the operation, and the decidua tissue was fresh;

[0027] NOD-SCID mice, 6-8 weeks old, sexually mature, female, weighing 20-25 g.

[0028] Shipping: Put the decidua into a 5ml sterile bottle of RPMI-1640 culture medium, then place it in an ice box and send it to the laboratory for inoculation. RPMI-1640 culture medium contains 100U / ml penicillin and 100U / ml streptomycin.

[0029] Rinse: wash away blood clots and mucus with 2-6°C sterile phosphate-buff...

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Abstract

An endometriosis model with obvious and stable characteristics is created through taking the decidue tissue from the woman suffering from artificial autoabortion, transplating it under the abdominal skin of NOD-SCID mouse, and stitching with aseptic suture silk.

Description

Technical field: [0001] The invention relates to a model of endometriosis and a method for establishing the model Background technique: [0002] Endometriosis is a common and frequently-occurring disease among women of childbearing age, and its incidence is on the rise, reaching 10-15% at present, accounting for more than 30% of general gynecological procedures. Dysmenorrhea, lower abdominal pain, and dyspareunia caused by endometriosis seriously affect women's health and quality of life, and are also one of the main causes of infertility. Endometriosis has extensive lesions, various shapes, and malignant biological behaviors of infiltration, metastasis, and recurrence, making it an intractable disease. The exact etiology and pathophysiological mechanism are not yet clear, and it needs to be confirmed by laparoscopy or surgical pathological examination, and the drug treatment and postoperative recurrence rate are high. [0003] The spontaneous occurrence and development of...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 凌斌王群华赵卫东祝怀平陈峥峥陈纲周颖沈国栋朱园园陈敏许恬怡姚凤球
Owner ANHUI PROVINCIAL HOSPITAL
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