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Powder injection for intravenous injection and its preparing method

A technology for powder injection and preparation process, applied to pneumonia, can solve the problems of affecting the curative effect of medicines, ignoring wogonin, and low content of active ingredients, and achieve the effects of facilitating the preparation of modern preparations, improving the curative effect of drugs, and reducing the dosage.

Active Publication Date: 2005-05-18
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They use the same conventional extraction and refining methods as other Yinhuang infusions: the extraction of honeysuckle takes chlorogenic acid as an index, while ignoring the effect of active ingredients such as isochlorogenic acid, and the content of chlorogenic acid is too low, a large number of impurities and ineffective ingredients have a negative effect on the drug. The safety and stability of Scutellaria baicalensis is a great threat; the extraction process of Scutellaria baicalensis is based on baicalin, and some have high purity but ignore the effect of active ingredients such as wogonin, which affects the curative effect of the drug
Conventional preparations use extracts as medicines, respectively using chlorogenic acid and baicalin as indicators, the content of active ingredients is low, and the ingredients in the extracts are not clear, leaving hidden dangers to the safety and stability of the drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0362] Chlorogenic acid 0.1g

[0363] Baicalin 40g

[0364] Sodium chloride 55g

[0365] Weigh sodium chloride, add appropriate amount of water for injection and stir to dissolve. Put the amount of chlorogenic acid and baicalin into the water for injection, add an appropriate amount of 50% sodium hydroxide solution under stirring to dissolve the chlorogenic acid and baicalin, and control the pH value of the liquid to be lower than 7.5. Add the sodium chloride of feeding amount again, stir to dissolve, add water for injection to about 550ml. Use 1mol / L hydrochloric acid and 1mol / L sodium hydroxide to adjust the pH value of the medicinal solution, so that the pH value of the medicinal solution is within the range of 6.0-6.8. Add activated carbon with 0.2% liquid medicine amount, raise the temperature to 70° C., and stir for 30 minutes. Use a sand filter rod and a vacuum pump to filter the liquid medicine. Use 1mol / L sodium hydroxide to adjust the pH value of the liquid to 5...

Embodiment 2

[0367] Chlorogenic Acid 25g

[0368] Baicalin 1.6g

[0369] Sodium chloride 67g

[0370] Take sodium chloride, add appropriate amount of water for injection and stir to dissolve. Put the amount of chlorogenic acid and baicalin into the water for injection, add an appropriate amount of 50% sodium hydroxide solution under stirring to dissolve the chlorogenic acid and baicalin, and control the pH value of the liquid to be lower than 7.5. Add the sodium chloride of feeding amount again, stir to dissolve, add water for injection to about 500ml. Use 1mol / L hydrochloric acid and 1mol / L sodium hydroxide to adjust the pH value of the medicinal solution, so that the pH value of the medicinal solution is within the range of 6.0-6.8. Add activated carbon with 1% liquid medicine amount, heat up to 80°C, and stir for 40 minutes. Use a sand filter rod and a vacuum pump to filter the liquid medicine. Use 1mol / L sodium hydroxide to adjust the pH value of the liquid to 8.0. Use a filter t...

Embodiment 3

[0372] Chlorogenic Acid 25g

[0373] Baicalin 40g

[0374] Sodium chloride 35g

[0375] Take sodium hydroxide, add appropriate amount of water for injection and stir to dissolve. Put the amount of chlorogenic acid and baicalin into the water for injection, add an appropriate amount of 50% sodium hydroxide solution under stirring to dissolve the chlorogenic acid and baicalin, and control the pH value of the liquid to be lower than 7.5. Add the sodium chloride of feeding amount again, stir to dissolve, add water for injection to 900ml. Use 1mol / L hydrochloric acid and 1mol / L sodium hydroxide to adjust the pH value of the medicinal solution, so that the pH value of the medicinal solution is within the range of 6.0-6.8. Add activated carbon with 1% liquid medicine amount, raise the temperature to 75° C., and stir for 20 minutes. Use a sand filter rod and a vacuum pump to filter the liquid medicine. Use 1mol / L sodium hydroxide to adjust the pH value of the liquid to 7.0. Use ...

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Abstract

The present invention discloses a kind of medicine powder for intravenous injection and its preparation process. The medicine is prepared with chlorogenic and baicalin as material. The medicine has obvious curative effect on upper respiratory tract infection, pneumonia and viral respiratory tract infection.

Description

technical field [0001] The invention relates to a powder injection for treating upper respiratory infection and pneumonia and resisting upper respiratory virus. Specifically, it is a powder injection prepared from Chinese herbal medicine, and also relates to a preparation method of the medicine. Background technique [0002] In my country, upper respiratory tract infections such as pharyngitis and tracheitis, pneumonia and respiratory virus infection are common and frequently-occurring diseases. Not only itself often protracted, but also can cause a variety of complications, endangering human health. With the development of industrial society, the air is polluted to varying degrees, which increases the incidence of upper respiratory tract infections and pneumonia-like diseases such as rhinitis and pharyngitis. Modern medicine believes that although the main pathogenic bacteria of this disease are streptococci, mixed infections of bacteria and viruses are not uncommon, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61P11/00G01N30/02G01N33/15
Inventor 赵志全
Owner LUNAN HOPE PHARM CO LTD
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