Array continuous preparing chromatography system and using method thereof

A chromatographic system and array technology, which are applied in the field of large-scale multi-component continuous preparative chromatography system and array type continuous preparative chromatography system, can solve the problems of impurity, difficulty and difficulty in amplification of pressure-bearing parts, and avoid diffusion. , to avoid dynamic sealing problems, to amplify the effect of easy

Inactive Publication Date: 2005-03-23
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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Problems solved by technology

Annular chromatography is suitable for the separation of multi-component systems, but it is difficult to scale up, and it involves the dynamic sealing of pressure-bearing parts and the impurity of products caused by the radial diffusion of solutes during the movement of the cylinder wall, so this The actual promotion of chromatography technology is more difficult

Method used

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  • Array continuous preparing chromatography system and using method thereof
  • Array continuous preparing chromatography system and using method thereof

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Embodiment Construction

[0020] The present invention will be further described below in conjunction with drawings and embodiments. See figure 1 , the embodiment of the array type continuous preparative chromatographic system of the present invention comprises:

[0021] Array chromatographic column 1 is composed of 20-100 chromatographic columns with identical specifications;

[0022] The solvent storage container 9, the solvent pump 4, and the main solvent control valve 41, wherein the solvent storage container 9, the solvent pump 4, and the main solvent control valve 41 are connected in sequence through pipelines, and then connected to each column of the array chromatographic column 1 through the pipelines. The top inlet is connected;

[0023] The raw material storage container 10, the raw material pump 3, and the main feed control valve 31, wherein, the raw material storage container 10, the raw material pump 3, and the main feed control valve 31 are connected in sequence through pipelines, and t...

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Abstract

The invention discloses an array style continuous preparation chromatogram system and its using method, the system includes separating part, material transporting part, solvent transporting part, collecting part and controlling part, and the separating part includes array chromatogram column, which is composed of at least two chromatogram columns. When continuously and equably sending into the array chromatogram columns, the feed-in controlling valve is controlled by the controlling computer and controlling closet, simulating circular chromatogram feed-in style switching in turn, periodically, equably feed-in to each chromatogram column, the purging product is collected by special collecting equipment of array chromatogram, controlled by the controlling part, then sending them to the products storing container. The system is suitable to several group continuous large-scale preparation.

Description

technical field [0001] The invention relates to the field of large-scale multi-component continuous preparation chromatographic systems, in particular to the field of array type continuous preparation chromatographic systems. Background technique [0002] Chromatography is a technical system that separates the components in a mixture from each other through the different retention times caused by the different forces between the two phases. Chromatography can be divided into analytical-level chromatography and preparative-level chromatography according to its use. The former has a very low detection limit, can detect trace components contained in the mixture, and is mainly used for substance identification; the latter is mainly used for the separation and purification of active ingredients in substances, and is suitable for large-scale preparation and industrial production. Preparative chromatography can be divided into batch operation and continuous operation according to ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/08G01N30/46G01N30/58G01N30/84
Inventor 陈福明宋华
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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