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Method of ion liqid extraction for separating penicillin

A technology of ionic liquid and penicillin, applied in organic chemistry and other fields, can solve problems such as emulsification

Inactive Publication Date: 2005-01-12
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems such as emulsification in the process of extracting penicillin in a molecular solvent, and provide a method for extracting and separating penicillin with a simple ionic liquid, which not only makes the extraction system cheap, reduces production costs, but also improves product quality. quality

Method used

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  • Method of ion liqid extraction for separating penicillin
  • Method of ion liqid extraction for separating penicillin
  • Method of ion liqid extraction for separating penicillin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Accurately measure the penicillin G aqueous solution 350ml that concentration is 31276u / ml, the ionic liquid [Bmim]PF 6 Compared with the penicillin aqueous solution, add it into the mixing tank with a stirring device (single-stage extraction) at a ratio of 1:1.5, start the stirring, and fully mix the two phases. 2 SO 4 , control the pH value at 1.5, 2.0, 2.5, 3.0, 3.8 respectively, stir for 15 minutes, stand still and separate the phases. After the two-phase interface is clear, use a pipette to take the heavy phase ionic liquid to measure its optical rotation value. The reference penicillin in the ionic liquid The concentration of penicillin in the ionic liquid was obtained from the dissolution standard optical rotation curve in the ionic liquid, and the phase volume of the ionic liquid was accurately measured, and the calculated extraction rates were 83.46%, 84.59%, 83.44%, 73.06%, and 43.82%, respectively. Show the relationship between pH value and extraction rate. ...

Embodiment 2

[0025] Accurately measure 350ml of penicillin G aqueous solution with a concentration of 31566u / ml, ionic liquid [Bmim]PF 6 Compared with penicillin aqueous solution, it is 1:1.5, 1:2.0, 1:2.5, 1:3.0 and added to the mixing tank with stirring device (single-stage extraction), and the stirring is started to fully mix the two phases, and the temperature is controlled at 5 ℃~10℃, slowly add 10wt% H 2 SO 4 , control the pH to 2.0, stop stirring after stirring for 15 minutes, stand still and separate the phases. After the two-phase interface is clear, use a pipette to take the heavy phase ionic liquid to measure its optical rotation value, and refer to the standard optical rotation curve of penicillin dissolved in the ionic liquid. The concentration of penicillin in the ionic liquid was obtained, and the phase volume of the ionic liquid was accurately measured. The calculated extraction rates were 91.62%, 86.07%, 85.93%, and 86.21%, respectively. Indicates the relationship betwee...

Embodiment 3

[0027] Accurately measure 350ml of penicillin G aqueous solution with a concentration of 19700u / ml, 31384u / ml, 42409u / ml, 52757u / ml, 60725u / ml and add it to a mixing tank with a stirring device. The ionic liquid [Bmim]PF 6 Compared with penicillin aqueous solution, it is 1:1.5 to add at one time, start stirring, so that the two phases are fully mixed, the temperature is controlled at 5 ° C ~ 10 ° C, slowly add 10wt% H 2 SO 4 , control the pH value to 2.0, stir for 15 minutes, stand still and separate the phases. After the two-phase interface is clear, use a pipette to take the heavy phase ionic liquid to measure its optical rotation value, and refer to the standard optical rotation curve of penicillin dissolved in the ionic liquid to obtain the ion The concentration of penicillin in the liquid, the volume of the ionic liquid phase is accurately measured, and the calculated extraction rates are 89.23%, 91.62%, 91.83%, 91.57%, and 90.02%, respectively. Show the relationship bet...

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Abstract

This invention relates to method for extracting penicillin by ion-liquid extract. In this invention, determinations are: extraction procedures, pH value, phase ratio, extration rate affected by penicillin concentration. Extraction types are; single stage extraction, cross current extraction and counter current extraction. Said extract ion-liquid is [BMIM]PF6(1-ethyl-3-methyl imidazole hexafluorophosphate. This invention determines back-extraction method.

Description

technical field [0001] The invention relates to the field of liquid-liquid extraction, in particular to a penicillin extraction and stripping method using ionic liquid as an extraction agent. Background technique [0002] Penicillin is an antibiotic widely used clinically. In recent years, with the development of semi-synthetic pharmaceutical technology, penicillin has been widely used as a raw material for the synthesis of β-lactam drugs. Penicillin production generally consists of fermentation, solvent extraction, back extraction, crystallization, drying and other processes, among which solvent extraction and back extraction are important steps. Continuous research and development of new extraction systems is a problem that researchers have been paying attention to. [0003] At present, the extraction systems that have been studied more include butyl acetate extraction system, organic amine extraction system, neutral phosphine extraction system, ...

Claims

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Application Information

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IPC IPC(8): C07D477/02
Inventor 刘庆芬余江王佳玉王玉红杨屏胡雪生夏寒松刘会洲
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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