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Method for forming osteolith class layer on surface of calcium phosphate ceramics

A technology of calcium phosphate ceramics and apatite, applied in the direction of bone implants, etc., can solve the problems of uneven distribution, high process cost, complicated device, etc., and achieve the effect of fast deposition rate, high surface activity, and growth promotion.

Inactive Publication Date: 2005-01-12
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The device that this method uses is comparatively complicated, and process cost is high; The speed of forming bone-like apatite on the surface of calcium phosphate ceramics is slow, and quantity is few, and bone-like apatite is distributed unevenly on the surface of calcium phosphate ceramics, has affected calcium phosphate ceramics on the surface of calcium phosphate ceramics. Practical Application in Clinical Medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Clean the porous calcium phosphate ceramics prepared by artificial synthesis in deionized water or distilled water, and dry them at 80°C;

[0018] (2) prepare 12 moles of sodium hydroxide aqueous solution with analytically pure sodium hydroxide reagent and deionized water or distilled water;

[0019] (3) Add 24.00 grams of sodium chloride (NaCl) and sodium bicarbonate (NaHCO) to 1000 ml of deionized water or distilled water 3 ) 1.01 grams, potassium chloride (KCl) 0.69 grams, dipotassium hydrogen phosphate (K 2 HPO 4 ·3H 2 O) 0.69 g, magnesium chloride (MgCl 2 ·6H 2 O) 0.93 g, calcium chloride (CaCl 2 2H 2 O) 0.84 grams, sodium sulfate (Na 2 SO 4 ) 0.21 g, Tris (CH 2 Oh) 3 CNH 2 ) 18.18 grams, prepare simulated body fluid, and adjust the pH value of simulated body fluid to 7.2~7.4 with 1 mole hydrochloric acid solution, prepare simulated body fluid;

[0020] (4) Place the calcium phosphate ceramics cleaned in step (1) in a glass container, add the 12 mol...

Embodiment 2

[0025] (1) Clean the porous calcium phosphate ceramics prepared by the coral conversion method in deionized water or distilled water, and dry at 90°C;

[0026] (2) Prepare 8 moles of sodium hydroxide aqueous solution with analytically pure sodium hydroxide reagent and deionized water or distilled water;

[0027] (3) Add 12.00 grams of sodium chloride (NaCl) and sodium bicarbonate (NaHCO) to 1000 ml of deionized water or distilled water 3 ) 0.525 grams, potassium chloride (KCl) 0.345 grams, dipotassium hydrogen phosphate (K 2 HPO 4 ·3H 2 O) 0.345 grams, magnesium chloride (MgCl 2 ·6H 2 O) 0.465 grams, calcium chloride (CaCl 2 2H 2 O) 0.42 grams, sodium sulfate (Na 2 SO 4 ) 0.105 g, Tris (CH 2 Oh) 3 CNH 2 ) 9.09 grams to prepare a simulated body fluid, and adjust the pH value of the simulated body fluid to 7.2 to 7.4 with 1 mole of hydrochloric acid solution; prepare the simulated body fluid;

[0028] (4) Place the calcium phosphate ceramics cleaned in step (1) in a ...

Embodiment 3

[0033] (1) Clean the porous calcium phosphate ceramics prepared by the natural bone calcination method in deionized water or distilled water, and dry them at 100°C;

[0034] (2) Prepare 1 mole of sodium hydroxide aqueous solution with analytically pure sodium hydroxide reagent and deionized water or distilled water;

[0035] (3) Add 8.00 grams of sodium chloride (NaCl) and sodium bicarbonate (NaHCO) to 1000 ml of deionized water or distilled water 3 ) 0.35 grams, potassium chloride (KCl) 0.23 grams, dipotassium hydrogen phosphate (K 2 HPO 4 ·3H 2 O) 0.23 g, magnesium chloride (MgCl2 ·6H 2 O) 0.31 g, calcium chloride (CaCl 2 2H 2 O) 0.28g grams, sodium sulfate (Na 2 SO 4 ) 0.07 g, Tris (CH 2 Oh) 3 CNH 2 ) 6.06 grams, prepare simulated body fluid, and adjust the pH value of simulated body fluid to 7.2~7.4 with 1 mole hydrochloric acid solution, prepare simulated body fluid;

[0036] (4) Place the calcium phosphate ceramics cleaned in step (1) in a glass container, add...

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Abstract

In the invention, calcium phosphate ceramics is soaked by 1-12 mole sodium hydroxide solution, then is soaked and processed by iimitate body fluid with different density to form bone-like kietyoite layer on the surface of calcium phosphate ceramics.

Description

technical field [0001] The invention belongs to the technical field of surface active treatment of calcium phosphate ceramics, in particular to a method for forming a bone-like apatite layer on the surface of calcium phosphate ceramics. Background technique [0002] The chemical composition of calcium phosphate ceramics is similar to the inorganic components of human bone, and it has good biocompatibility. It is a very important material for bone defect repair. The preparation methods of calcium phosphate ceramics mainly include artificial synthesis method, coral transformation method and natural bone calcination method. During the preparation process of the above methods, high-temperature sintering treatment at about 1000 ° C is required to reduce the biological activity of calcium phosphate ceramics. Implantation of medical materials in the body affects the adhesion, proliferation and growth of cells and tissues on them. Actively treating the surface of calcium phosphate ...

Claims

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Application Information

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IPC IPC(8): A61F2/28C04B35/447C04B41/81C04B41/82C04B41/85
Inventor 田杰谟王晨董利民李兆新
Owner TSINGHUA UNIV
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