Amorphous cefditoren pivoxil composition and process for producing the same
A composition and amorphous technology, applied in the field of pharmaceutical compositions for oral administration, can solve the problems of unsatisfactory production efficiency, process management and long time, and achieve high therapeutic effectiveness, good dissolution and stability excellent effect
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[0063] Amorphous cefditoren and pivoxil compositions 1 to 7 of the present invention were prepared as follows.
[0064] Amorphous Composition 1
[0065] With 0.3g crystalline cefditoren pivoxil (manufactured by Meiji Seika Co., Ltd.), 2.7g sodium caseinate (manufactured by New Zealand Dairy Board) (the weight ratio of cefditoren pivoxil / casein sodium is 10 / 90) was put into a pulverizing container made of alumina, and pulverized for 30 minutes using a vibrating rod mill (manufactured by CMT, model TI-200) to obtain an amorphous composition 1.
[0066] Amorphous Composition 2
[0067] Mix 0.3 g of crystalline cefditoren pivoxil (manufactured by Meiji Seika Co., Ltd.), 2.7 g of crystalline cellulose (manufactured by Asahi Kasei Co., Ltd.) (the weight ratio of cefditoren pivoxil / crystalline cellulose is 10 / 90) was placed in a pulverizing container made of alumina, and pulverized for 30 minutes using a vibrating rod mill (manufactured by CMT: TI-200) to obtain an amorphous c...
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