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Complex external medicine speical for acne and preparing method thereof

A technology for external use medicine and compound prescription, applied in the field of external use medicine for treating acne, can solve the problems of storage conditions, shelf life and convenience of use, unstable quality, fluctuation of therapeutic effect, etc., and achieves satisfactory therapeutic effect, comprehensive therapeutic effect and long shelf life Effect

Inactive Publication Date: 2004-09-15
CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem with unilateral therapy is that it has a single effect and can only target 1-2 disease links at most (such as antibacterial plus anti-inflammatory, or antibacterial plus anti-angular suppository)
In addition, most of the above-mentioned acne keratolytic drugs have local irritation and / or allergic effects, and benzoyl peroxide has a strong oxidative effect. If they are composed of compound preparations, the quality is not easy to stabilize, which will cause fluctuations in the concentration and curative effect of compatible drugs. Storage conditions, shelf life and use Convenience and other aspects are greatly affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The effective active ingredients of this embodiment are all-trans retinoic acid 0.025% (weight percentage, the same below) and clindamycin hydrochloride 1%, and the matrix carrier is glycerin, cosolvent, azone, antioxidant and ethanol.

Embodiment 2

[0020] The effective active ingredients of this embodiment are 0.025% cisretinoic acid and 2% erythromycin, and the matrix carrier is glycerin, cosolvent, azone, antioxidant and ethanol.

Embodiment 3

[0022] 0.025% all-trans retinoic acid and 1% chloramphenicol are used as effective active ingredients in this embodiment, and glycerin, cosolvent, azone, antioxidant and ethanol are used as the matrix carrier.

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PUM

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Abstract

The present invention relates to a compound medicine for external application for curing acne and its preparation method. Its composition contains the following two active components: (wt%) 0.01-2% of tretinoin and 0.25-5% of antimicrobial. Said compound medicine can be made into liniment or anhydrous ointment, and has the following therapeutic functions, dissolving keratotic plug, regulating keratosis, resisting microbe, relieving inflammation and reducing secondary factor of sebaceous secretion, so that it can obtain obvious therapeutic effect.

Description

Technical field: [0001] The invention relates to a medicine for external use for treating acne, in particular to a compound medicine for external use specially treating acne and a preparation method thereof. Background technique: [0002] Acne is a chronic disease of the sebaceous glands. It can be divided into inflammatory and non-inflammatory acne. It is the second most common disease in dermatology. The incidence rate accounts for about 7-10% of skin diseases. The age of the disease covers 11-30 years old, men and women Anyone can suffer. [0003] It is now known that the following four pathogenic factors and links play a key role in the occurrence, development and outcome of acne: 1. The microbial action in the hair follicle and sebaceous unit, first is the anaerobic Propionibacterium acnes, and the second is the aerobic bacteria Predominant pyogenic bacteria such as epidermis and Staphylococcus aureus, it is believed that Saccharomyces is also involved in the pathogene...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4436A61K31/496A61K31/5383A61K31/65A61K31/7028A61K31/7048A61P17/10
Inventor 张崇璞郑家润陈沄李新宇徐兰芳唐美育高纪伟
Owner CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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