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Compound silver zinc sulfapyrimidine ointment, and its prepn. method

A technology of silver sulfadiazine and zinc sulfadiazine, which is applied in the field of drug preparation, can solve problems such as poor absorption, and achieve the effects of improving absorption and utilization, promoting wound healing, and synergistic effect and compatibility

Inactive Publication Date: 2004-07-21
YOULIKAI BIOLOGICAL TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to: overcome the shortcoming that the existing compound sulfadiazine zinc coating agent has poor absorption of wound exudates in the process of treating burns; Compound sulfadiazine silver-zinc ointment with astringent effect and manufacturing method thereof

Method used

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  • Compound silver zinc sulfapyrimidine ointment, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The formula of the compound sulfadiazine silver-zinc ointment provided in this example is: 2 grams of sulfadiazine silver, 5 grams of sulfadiazine zinc, 50 grams of azone, 1.0 grams of ethyl p-hydroxybenzoate, 85 grams of glyceryl monostearate, white 140 grams of petrolatum, 8 grams of sodium lauryl sulfate, 110 grams of glycerin, and 600 grams of distilled water.

[0026] Its preparation method: (1) Take the above-mentioned weighed oil phase: 85 grams of glycerol monostearate, 140 grams of white petrolatum, and 50 grams of azone; put it into a beaker and heat until it melts, keeping the temperature at about 75°C;

[0027] (2) In addition, take the above-mentioned weighed water phase components: 1.0 grams of ethyl p-hydroxybenzoate, 8 grams of sodium lauryl sulfate, 110 grams of glycerin and 600 grams of distilled water, put them into a beaker and heat to melt, and keep the temperature Around 75°C;

[0028] (3) Slowly add the melted oil phase components into the water ...

Embodiment 2

[0030] Formula 2 is: 25 grams of silver sulfadiazine, 50 grams of zinc sulfadiazine, 50 grams of azone, 1.0 grams of ethyl p-hydroxybenzoate, 50 grams of glyceryl monostearate, 10 grams of stearic acid, 50 grams of lanolin, 100 grams of white petrolatum, 10 grams of sodium lauryl sulfate, 100 grams of glycerin, and 550 grams of distilled water.

[0031] Its preparation method: (1) take the above-mentioned weighed oil phase: 50 grams of glyceryl monostearate, 10 grams of stearic acid, 50 grams of lanolin, 100 grams of white petrolatum, and 50 grams of azone; put it into a beaker Heat it until it melts, and keep the temperature at about 75°C;

[0032] (2) Take the above-mentioned weighed water phase components in addition: 1.0 grams of ethyl p-hydroxybenzoate, 10 grams of sodium lauryl sulfate, 100 grams of glycerin and 550 grams of distilled water; put into a beaker and heat to melt, keep The temperature is about 75°C;

[0033] (3) Slowly add the melted oil phase ingredients ...

Embodiment 3

[0035] Formula 3 is: 10 grams of silver sulfadiazine, 10 grams of zinc sulfadiazine, 20 grams of azone, 100 grams of glycerin, 30 grams of propylene glycol, 1.0 grams of ethyl p-hydroxybenzoate, 50 grams of glyceryl monostearate, stearic acid 10 grams, 150 grams of white petrolatum, 10 grams of sodium lauryl sulfate, 609 grams of distilled water.

[0036] Its preparation method: (1) take the above-mentioned weighed oil phase: 50 grams of glyceryl monostearate, 10 grams of stearic acid, 150 grams of white vaseline, 20 grams of azone and 30 grams of propylene glycol; put into a beaker and heat Until melting, keep the temperature around 75°C;

[0037] (2) Take the above-mentioned weighed water phase components in addition: 1.0 grams of ethyl p-hydroxybenzoate, 100 grams of glycerin, 10 grams of sodium lauryl sulfate and 609 grams of distilled water; put them into a beaker and heat to melt, and keep the temperature Around 75°C;

[0038] (3) Slowly add the melted oil phase compon...

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Abstract

A compound sulfapyrimidine silver zinc ointment for treating burn is prepared from sulfapyrimidine silver, sulfapyrimidine zinc, osmotic aid medical auxiliary, ethyl p-hydroxybenzoate, glycerine and distilled water through heating oil phase to 75 deg.C, heating water phase to 75 deg.C, slowly adding oil phase to water phase while stirring, cooling, adding sulfapyrimidine silver and sulfapyrimidine zinc, grinding, and examining. Its advantage is strong antibacterial function.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a compound sulfadiazine silver-zinc ointment, which is a chemical external medicine for treating burns, and a production method. technical background [0002] Burns are a common trauma during wartime and peacetime. With the popularization of electricity in production and daily life, and the use of chemicals in industry, the number of burns is large even in peacetime. Burns are the damage to the outer skin, and the burn wound is the main way to cause systemic infection. Grasping the treatment of burn wounds is the key to curing burn patients. Controlling infection and promoting healing are the goals of burn wound treatment and the basic requirements for external use of burn wounds. [0003] In 1974, American professor Fox invented the silver salt of sulfadiazine and used it in clinical treatment, which played a good role in controlling the bacterial infection of burn wounds, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/555A61P17/02
Inventor 孙世章高志军张琳
Owner YOULIKAI BIOLOGICAL TECH BEIJING
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