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Stabilized compositions having antibacterial activity

A composition and active technology, applied in organic chemistry, animal repellent, plant growth regulator, etc., can solve the problems of low solubility, lack of light stability, limited solubility, etc.

Inactive Publication Date: 2004-01-07
COLOPLAST AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its main disadvantages are the compound's low solubility and lack of sufficient stability to radiation and light
Silver allantoate is also less stable to light and has limited solubility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] Silver Hydantoin: Dissolve 12g hydantoin and 100ml 1M NaOH in 100ml purified water. Slowly add 16.3g AgNO dissolved in 50ml purified water while stirring 3 . The suspension was stirred for 2 hours, allowed to stand and filtered. The white solid was resuspended in 200 ml of purified water, stirred for 2 hours, filtered, washed with acetone and dried. Yield 19.0 g (96%).

[0079] 5,5-Dimethyl-hydantoin silver: 12.3 g of 5,5-dimethyl-hydantoin and 4.2 g of NaOH were dissolved in 150 ml of purified water. Slowly add 16.3g AgNO dissolved in 50ml purified water while stirring 3 . The suspension was stirred for 2 hours, allowed to stand and filtered. The white solid was resuspended in 200 ml of purified water, stirred for 2 hours, filtered, washed with acetone and dried.

[0080] 5,5-Diethyl-hydantoin silver: 1.87 g of 5,5-diethyl-hydantoin and 10.0 ml of 1M NaOH were dissolved in 20 ml of purified water. Slowly add 1.70 g of AgNO dissolved in 10 ml of purified ...

Embodiment 3

[0086] Determination of Relative UV Stability of Complexes

[0087] Silver allantoate: Attempts to prepare complexes according to US2,336,131 resulted in a very discolored product, (making UV light stability tests meaningless), so an improved process was used:

[0088] 1.897g of allantoin (12mmol) was suspended in 20ml of purified water, and 10.0ml of 1M NaOH (10mmol) was added. Slowly add 1.70 g of AgNO dissolved in 10 ml of purified water while stirring 3 (10 mmol), the suspension was filtered, rinsed with purified water and acetone and dried to yield a white firm solid with no trace of discoloration. Grind with a mortar and set aside.

[0089] Ag-5,5-diphenyl-hydantoin 1:1

Embodiment 4

[0093] Preparation of Stabilized Silver Solution (SSS)

[0094] Dissolve 79.2 g (0.6 mol) of 5,5-dimethylhydantoin, 17.2 g (0.43 mol) of sodium hydroxide and 34 g (0.2 mol) of silver nitrate in 1 liter of purified water (silver nitrate and 5,5-di Methylhydantoin is dissolved separately and mixed when the two solutions are clear, thus avoiding precipitation). This solution is called a stabilized silver solution (SSS). The silver concentration in SSS is about 2% w / w. The SSS can be easily incorporated into wet and dry wound care products due to the stability of the SSS used to obtain antimicrobial wound care dressings.

[0095] The following 4 examples demonstrate how to incorporate SSS into foams, amorphous hydrogels and hydrogel sheets. In all 3 categories of products mentioned above, other formulations can also be used simply to prepare products. The SSS can be included in almost any other product category, such as films, alginates, water fibers, gauze, etc.

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PUM

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Abstract

A stabilised composition having antibacterial, antiviral and / or antifungal activity, said composition comprising silver ions and a ligand, characterised in that the composition comprises a complex of silver and a ligand selected from the group consisting of 5,5-disubstituted hydantoins in which the substituents do not comprise conjugated unsaturated bonds and barbituric acid and derivatives thereof stabilising silver ions against reduction to free silver in a hydrophilic environment, and that the composition has a solubility in water higher than 10 mg Ag / l is stable during sterilisation and retains the activity without giving rise to darkening or discoloration of the dressing during storage.

Description

technical field [0001] The present invention relates to stable compositions having antibacterial, antiviral and / or antifungal activity, the invention also relates to methods of producing such compositions, medical devices having coatings containing such compositions, and said stable compositions Uses for the production of wound dressings, ostomy appliances, incontinence devices, other medical devices or hydrophilic coatings. [0002] The antimicrobial activity of silver compounds is a known property and it has been used for many years. The bacteriostatic and fungistatic effects are caused by silver ions and a single compound, one example of which has been used clinically is silver nitrate. Silver nitrate at a concentration of 0.5-1% in water shows disinfectant properties and is useful in preventing infection of burns or in preventing neonatal conjunctivitis. For another silver compound, silver sulfadiazine, the antibacterial effect of sulfadiazine molecules can be further im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/16A01N25/02A01N25/10A01N43/50A01N43/54A01N55/02A01N59/16A61F13/00A61L15/44A61L26/00A61L29/00C07D233/74C07D233/80C07D233/88C07D239/62
CPCA61L2300/802A61L2300/404C07D233/88A01N43/50C07D239/62C07D233/80A61L29/16A01N59/16A01N43/54A61L2300/104A61L29/085C07D233/74A61L26/0066A01N25/34A01N25/22A01N25/16A01N25/04A01N2300/00
Inventor J·范格B·尼尔森
Owner COLOPLAST AS
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