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Process for extracting leonuridine from fresh motherwort and leonuridine preparation

A technology for fresh motherwort and motherwort, which is applied to the extraction process of traditional Chinese medicine and the field of preparation thereof, can solve the problems of large dosage, unstable drug effect, unrefined preparation and the like

Inactive Publication Date: 2003-11-19
ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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  • Abstract
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Problems solved by technology

[0004] Motherwort is a gynecological sacred medicine with definite curative effect and wide application. There are many kinds of preparations used in clinical practice, such as motherwort ointment, motherwort oral liquid, motherwort tablets, etc., but they are all prepared by general water extraction or water extraction and alcohol precipitation. The preparations are not refined, and the taste is bitter. The shortcomings of large dosage and unstable drug effect, the total alkaloids of motherwort preparations include total alkaloids of motherwort capsules, total alkaloids of motherwort tablets, total alkaloids of motherwort injection, successfully overcome the above shortcomings, with refined preparations, no bitterness, small dosage, and high efficacy Stability and other advantages, so it is easier to be accepted by people, has broad market prospects, and is an ideal product for modern pharmaceutical companies

Method used

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Embodiment Construction

[0057] The best embodiment of the invention is to clean the fresh motherwort, remove impurities and wash it, and pass the inspection for later use; take the fresh motherwort and break it, beat the pulp, squeeze the juice, take the juice, add appropriate amount of water to mix the residue and squeeze the juice, repeat 2-3 times , combine the juices, add ethanol under stirring to make the alcohol content 40-80%, let it stand, filter, take the filtrate to recover the ethanol, adjust the pH to 2-3 with hydrochloric acid, filter, put the filtrate on an acidic cation exchange resin column, After the exchange, the resin is washed with water until the pH of the water eluent is 6-7, discarded, and continued to be eluted with 5-20% acid or 5-20% ammonia water until the alkaloid is completely extracted. Collect the eluent, adjust the pH to 6-7, filter, concentrate the filtrate, dry, extract the alkaloids from the dry product with ethanol until complete, filter, recover the ethanol from th...

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Abstract

A process for extracting leonurine from fresh motherwort includes such steps as extracting juice, depositing in alcohol, filtering, column exchanging, eluting, concentrating and drying. Said leonurine can be made into capsule, tablet, or injection for treating gynopathy with hige curative effect.

Description

technical field [0001] The invention relates to an extraction process of traditional Chinese medicine and its preparation, in particular to an extraction process of fresh motherwort total alkaloids and its preparation. Background technique [0002] Motherwort is a plant of Labiatae, listed as the top grade in "Shen Nong's Materia Medica", and it has been recorded in successive dynasties of herbal medicines. It is a traditional gynecological medicine. Wide range of clinical applications, for irregular menstruation, dysmenorrhea, amenorrhea, lochia; edema, oliguria, acute nephritis edema embolism. [0003] "Chinese Pharmacopoeia" 2000 edition contains two kinds of motherwort dry and fresh products. The fresh product is harvested from the seedling stage in spring to the early flowering stage in early summer; the dry product is harvested when the stems and leaves are lush in summer, the flowers are not blooming or just blooming, and dried in the sun. Th...

Claims

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Application Information

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IPC IPC(8): A61K31/221A61P15/00C07C279/06
Inventor 毛友昌毛晓敏
Owner ZHEJIANG DADE PHARMACEUTICAL GROUP CO LTD
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