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Hiliezdum fast-release tablet and preparing method thereof

A technology for saccharin and immediate-release tablets, which is applied in the directions of pill delivery, pharmaceutical formulations, nervous system diseases, etc., can solve the problems of restricting drug dissolution, increasing production processes, increasing production costs, etc., and achieving easy availability of auxiliary materials and preparation technology Simple, good-tasting results

Inactive Publication Date: 2003-11-12
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the bitter taste of Shenshouguosu, the currently marketed solid preparations are in the form of coated tablets to improve the compliance of patients. However, the coating process increases the production process and increases the production cost on the one hand; on the other hand, the sugar coating also limits The dissolution of the drug affects the efficacy of the drug

Method used

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  • Hiliezdum fast-release tablet and preparing method thereof
  • Hiliezdum fast-release tablet and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The tablets are prepared. Components are shown in Table 1

[0025] Table 1 Prescription of Shenshuaiguosu Immediate-release Tablet Example 1

[0026] Component Feeding amount (mg / t) Composition ratio of tablet (%)

[0027] Raw material medicine of Shenshuengguo 25.0 10.0

[0028] Sorbitol P60 81.3 32.5

[0029] Microcrystalline Cellulose PH102 125.0 50.0

[0030] Sodium carboxymethyl starch 12.5 5.0

[0031] Micronized silica gel 3.7 1.5

[0032] Magnesium stearate 1.5 0.6

[0033] Mint flavor 1.0 0.4

[0034] Total 250.0 100.0

[0035] Tablets are prepared as follows:

[0036] The raw material drug of Shenshouguo is passed through a 40-mesh sieve, mixed with sorbitol, microcrystalline cellulose PH102, micronized silica gel and essence, granulated with 2.0% PVP ethanol solution, dried, and granulated through a 40-mesh sieve to obtain Shenshouguo Plain gra...

Embodiment 2

[0038] Example 2: Preparation of the tablet. Components are shown in Table 2

[0039] Table 2 Prescription of Shenshuaiguosu Immediate Release Tablet Example 2

[0040]Component Feeding amount (mg / t) Composition ratio of tablet (%)

[0041] Raw material medicine of Shenshenguosu 75.0 30.0

[0042] Sorbitol P60G 100.0 40.0

[0043] Microcrystalline Cellulose PH101 62.5 25.0

[0044] Croscarmellose Sodium 5.0 2.0

[0045] Micronized silica gel 3.7 1.5

[0046] Magnesium stearate 2.8 1.1

[0047] Mint flavor 0.5 0.2

[0048] Aspartame 0.5 0.2

[0049] Total 250.0 100.0

[0050] Tablets are prepared as follows:

[0051] Shenshuaiguo raw material is passed through a 40-mesh sieve, mixed with sorbitol, microcrystalline cellulose PH101, micronized silica gel and flavoring agent, PVP and eucalyptus oil are dissolved in 90% ethanol / water solution, the concentrations are 1.0% and 0.2% respectively %, to obtain a binding solution, granulate,...

Embodiment 3

[0054] The tablets are prepared. Components are shown in Table 3

[0055] Table 3 Prescription of Shenshuaiguosu Immediate Release Tablet Example 3

[0056] Component Feeding amount (mg / t) Composition ratio of tablet (%)

[0057] Raw material medicine of Shenshuengguo 50.0 25.0

[0058] Xylitol DC 40.0 20.0

[0059] Microcrystalline Cellulose PH101 66.0 33.0

[0060] Microcrystalline Cellulose PH102 30.0 15.0

[0061] Croscarmellose Sodium 10.0 5.0

[0062] Micropowder silica gel 1.6 0.8

[0063] Magnesium stearate 2.0 1.0

[0064] Orange flavor 0.2 0.1

[0065] Aspartame 0.2 0.1

[0066] Total 200.0 100.0

[0067] Shenshouguo raw material is passed through a 40-mesh sieve, mixed with fillers, micropowdered silica gel, aspartame and essence, granulated with 2.5% PVP in 95% ethanol / water solution, dried, and granulated through a 40-mesh sieve to obtain Shens...

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PUM

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Abstract

The invention is a kind of quick-released tablet of shenshuai fruit elements and the manufacturing method. The tablet contains 10-30 % shenshuai fruit element extraction material, 2-5 % sputtering agent, 1.5-3%, the other is filter. The sputtering agent is cross-linked sodium cellulose glycolate, sodium carboxy methyl starch or the compound of them. The additive includes lubricant, flow aid, deodorizing agent. The filler is the compound of alditol and cellulose. The method used polyketone as adhesive, used alcohol or the fixed liquid of alcohol and water as humectant. The sputtering agent uses inner adding method or outer adding method, wet process to produce particles. The character of the invention lies in fast dilution, the medicine can be dissolved entirely in then minutes, it needn't sugar-coat, the troche has good taste, it has no obvious bitterness.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine tablet, in particular to an immediate-release tablet with nephrin as an active ingredient and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique: [0002] With the accelerated pace of life, the impact of adverse environmental factors on human health has become increasingly prominent. Data show that the prevalence of neurosis is as high as 47.7‰, and neurasthenia is the main type, with a prevalence rate of 33.78‰, and similar symptoms are also very common in other mental diseases. However, in addition to adjusting the patient's life rhythm, antidepressants and anti-anxiety drugs are commonly used in the past, mainly Western medicines. The curative effect is often unsatisfactory and the side effects are relatively large. [0003] Shenshenguosu is a refined active ingredient extracted from the fruit of the wild plant Helicid hilgirica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61P25/20A61P25/22A61P25/24
Inventor 罗国安叶磊王义明刘建娣
Owner TSINGHUA UNIV
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