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Application of acetyl boswellic acid in preparing antitumor agent

A technology of boswellic acid and anti-tumor drugs, which can be applied in the directions of anti-tumor drugs, medical preparations containing active ingredients, organic active ingredients, etc., and can solve problems such as limiting the therapeutic effect of malignant tumors and toxic and side effects

Inactive Publication Date: 2003-08-20
INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many factors such as tumor invasion and metastasis and the resulting recurrence after treatment, strong toxic and side effects of anticancer drugs, and drug resistance of cancer cells still limit the therapeutic effect of malignant tumors.

Method used

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  • Application of acetyl boswellic acid in preparing antitumor agent
  • Application of acetyl boswellic acid in preparing antitumor agent
  • Application of acetyl boswellic acid in preparing antitumor agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] 1 kg of crude drug frankincense beads was percolated with 95% ethanol to obtain percolation; the solvent was recovered under reduced pressure to obtain 748.8 grams of ethanol paste. Dissolve the obtained ethanol paste in petroleum ether-ethyl acetate mixed solvent, add sodium carbonate solution (about 3000ml) to adjust the pH to 10, extract three times with petroleum ether-ethyl acetate mixed solvent 3000ml, and then adjust the water phase to 4N hydrochloric acid pH 3, extracted three times with 3000ml of petroleum ether-ethyl acetate mixed solvent, washed the organic phase twice with 1500ml of water, dehydrated with anhydrous sodium sulfate, filtered, concentrated to dryness, added methanol to concentrate and foam to obtain frankincense total acid foam 252.3. The total boswellic acids were chromatographed on a 200-300 mesh silica gel column and eluted with a gradient of petroleum ether-ethyl acetate to obtain 40.6 g of the crude product mixture of acetylboswellic acids ...

Embodiment 2

[0120] The acetylboswellic acid tablet is prepared according to methods known in the art, wherein the tablet contains 6%-10% acetylboswellic acid according to actual needs, and the content of acetylboswellic acid can also be increased or decreased.

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Abstract

The present invention is the application of acetyl boswellic acid (BC-4) extracted from Boswellia carterii Birdw as antitumor medicine, a secondary application. It is found that BC-4 has the functions of resisting the proliferation of tumor cell, inducing malignant tumor cell to death, inhibiting the proliferation of human umbilical vein endothelial cell, inhibiting animal's grafted tumor, inhibiting metastasis of malignant tumor, etc. Both in vivo and vitro tests show that BC-4 has very low toxicity and is one excellent antitumor medicine and tumor metastasis inhibitor.

Description

technical field [0001] The invention relates to a new application of pentacyclic triterpenes extracted from the traditional Chinese medicine frankincense, acetylboswellic acid (BC-4) in the preparation of antitumor agents, that is, the second use of the medicine. Background technique [0002] Cancer is a serious threat to human life. The combination of surgery, radiotherapy and chemotherapy has successfully improved the cure rate of various malignant tumors and reduced the mortality of cancer patients. However, many factors, such as tumor invasion and metastasis and resulting recurrence after treatment, strong toxic and side effects of anticancer drugs, and drug resistance of cancer cells, still limit the therapeutic effect of malignant tumors. The behavior of invasion and metastasis is the most essential characteristic of malignant tumors, and it is also the crux of the lethality of malignant tumors. Preventing the invasion and metastasis of carcinoma in situ with chemical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P35/00
Inventor 韩锐赵万洲付招娣刘红岩方起程周金云崔锐
Owner INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
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