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Drug composition containing cefazolin and beta-lactamase inhibitor

A technology of lactamase and cefazolin, which is applied in the direction of medical preparations containing active ingredients, active ingredients of heterocyclic compounds, antibacterial drugs, etc., to achieve the effect of solving the problem of drug resistance, enhancing activity, and expanding the scope of antibacterial

Inactive Publication Date: 2003-06-18
YOUCARE PHARMA GROUP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, no one has studied cefazolin in combination with clavulanic acid or tazobactam

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: Mix 250 mg of cefazolin and 250 mg of clavulanic acid thoroughly, and operate according to the powder injection preparation process procedure.

Embodiment 2

[0044] Example 2: Mix 250 mg of cefazolin and 125 mg of clavulanic acid thoroughly, and operate according to the powder injection preparation process procedure.

Embodiment 3

[0045] Example 3: Mix 250 mg of cefazolin and 62.5 mg of clavulanic acid thoroughly, and operate according to the powder injection preparation process procedure.

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PUM

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Abstract

An antibacterial composite medicine contains ancef or its salt and beta-lactamase inhibitor (tazobactam or clavulanic acid) in Wt ratio of (1-20):(1-5). Its advnatage is high synergistic antibacterial action.

Description

field of invention [0001] The present invention relates to a synergistic antibacterial pharmaceutical composition. Specifically, the pharmaceutical composition contains cefazolin and a β-lactamase inhibitor (tazobactam, clavulanic acid or a pharmaceutically acceptable salt thereof). It also relates to a method for preparing the pharmaceutical composition and the use of cefazolin and a β-lactamase inhibitor in the preparation of medicines for treating infectious diseases. Background of the invention [0002] Cefazolin is a known β-lactam antibiotic. The pharmacokinetic properties of this product are superior: high plasma protein binding rate, low distribution volume, and slow excretion rate, so the serum concentration is high and long-lasting. The treatment of diseases is often better than other first-generation cephalosporins, so it is widely used clinically. However, some data suggest that due to the instability of cefazolin to β-lactamase, some strains of Staphylococcus ...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K31/546A61P31/04
Inventor 金描真白云
Owner YOUCARE PHARMA GROUP
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