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Compound prepn containing prostaglandin E1, prostaglandin A1 and prostaglandin B1 and its prepn process and use

A prostaglandin and compound preparation technology, which is applied in the direction of medical preparations containing active ingredients, antiviral agents, and pharmaceutical formulas, can solve the problems of useless AIDS prevention and drug detoxification, and achieve the same physical and chemical properties and physiological effects without changing the therapeutic effect. Exact, novel formula and unique effect

Inactive Publication Date: 2003-05-14
蔡海德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no clinical reports of the above substances used alone for AIDS prevention and treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] formula:

[0027] Prostaglandin E 1 ≥97% 40-60mg

[0028] Prostaglandin A 1 ≥97% 20-40mg

[0029] Prostaglandin B 1 ≥97% 10-20mg

[0030] 2-Hydroxy-β-cyclodextrin 2-2.5 times prostaglandin E 1 moles

[0031] Low Molecular Dextran-40 40-50g

[0032] Sterile water for injection or normal saline 900ml

[0033] Prostaglandin E 1 , prostaglandin A 1 and prostaglandin B 1 Refined to a purity of more than 97%, and prostaglandin E 1 Impurities are only allowed to be prostaglandin A 1 or prostaglandin B 1 , likewise, prostaglandin A 1 Impurities are only allowed for prostaglandin E 1 or prostaglandin B 1 , prostaglandin B 1 Impurities are only allowed for prostaglandin E 1 or prostaglandin A 1 .

[0034] prostaglandin E 1 , prostaglandin A 1 and prostaglandin B 1 Make saturated absolute ethanol solutions respectively, mix the saturated absolute ethanol solutions of the three, if crystals are precipitated, add absolute ethanol dropwise until completely diss...

Embodiment 2

[0036] formula:

[0037] Prostaglandin E 1 ≥97% 40-60mg

[0038] Prostaglandin E 1 Potassium salt≥97% 20-40mg

[0039] Prostaglandin B 1 ≥97% 10-20mg

[0040] 2-Hydroxy-β-cyclodextrin 2-2.5 times prostaglandin E 1 moles

[0041] Low Molecular Dextran-40 50-60g

[0042] Sterile water for injection or normal saline 900ml

[0043] Concrete preparation method is identical with embodiment 1.

Embodiment 3

[0045] formula:

[0046] Prostaglandin E 1 ≥97% 40-60mg

[0047] Prostaglandin E 1 Sodium salt≥97% 20-40mg

[0048] Prostaglandin B 1 ≥97% 10-20mg

[0049] 2-Hydroxy-β-cyclodextrin 3-4 times prostaglandin E 1 moles

[0050] Low Molecular Dextran-40 65-70g

[0051] Absolute ethanol 10L

[0052] prostaglandin E 1 , prostaglandin E 1 Sodium salt and prostaglandin B 1 They were respectively dissolved in absolute ethanol to make saturated solutions, and the saturated absolute ethanol solutions of the three were added dropwise to the saturated absolute ethanol-free solution of 2-hydroxy-β-cyclodextrin, and stirred until completely dissolved.

[0053] Then add the remaining amount of absolute ethanol, add the excipient low molecular weight dextran-40, adjust the pH value to 7.5-8.0, use a 0.22μm membrane to filter out bacteria and remove insoluble particles, and then measure the bacterial endotoxin and clarity of the intermediate product After the concentration, pH value,...

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PUM

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Abstract

The present invention discloses a compound injection in absolut ethyl alcohol or compound powdered injection preparation of prostaglandin E1, prostaglandin E1 potassium salt, prostaglandin E1 sodium salt or prostaglandin A1 and prostaglandin B1. The compound preparation is used in preventing and treating AIDS and abstaining from drugs. It has unique recipe, complementary components, determined curative effect and less toxic side effect.

Description

Technical field: [0001] The present invention relates to a kind of medicine and its preparation method and application, especially a kind of medicine containing prostaglandin E 1 , prostaglandin A 1 and prostaglandin B 1 The compound preparation and its preparation method and application. Background technique: [0002] It is known that prostaglandin E 1 , prostaglandin E 1 Potassium or sodium salt, prostaglandin A 1 It can be used to treat hepatitis, and it is also a good drug for cardiovascular and cerebrovascular diseases. Prostaglandin B 1 prostaglandin E 1 Similar but weaker pharmacological effects. There is no clinical report that the above substances are used alone for AIDS prevention and drug rehabilitation. Invention content: [0003] The object of the present invention is to provide a prostaglandin E 1 , prostaglandin E 1 Potassium or sodium salt, prostaglandin A 1 and prostaglandin B 1 compound preparations. [0004] Another object of the present in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5575A61P25/36A61P31/18
Inventor 蔡海德
Owner 蔡海德
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