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Exterior-applied article for losing weight

A topical, oil-soluble technology, used in medical preparations containing active ingredients, metabolic diseases, organic active ingredients, etc., can solve problems such as increased heart rate, elevated blood pressure, and is not suitable for patients with cardiovascular and cerebrovascular diseases. Dry mouth, enhanced decomposition effect

Inactive Publication Date: 2002-11-13
曾仲韬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, sibutramine and fenfluramine belong to the central nervous system drugs, which can cause side effects such as dry mouth, increased heart rate, increased blood pressure, constipation, palpitation, etc., and are not suitable for the heart and brain. Vascular disease patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 2

[0031] 1. Choose an oil-soluble sibutramine such as sibutramine base.

[0032] 2. According to the weight ratio of the components, 0.1Kg of sibutramine base (0.1% by weight ratio), 10Kg of simethicone oil (10% by weight ratio), 34.9Kg of white oil (34.9% by weight ratio), 20Kg of olive oil (20% by weight ratio), 15Kg of azone (15% by weight ratio), and 20Kg of essence (20% by weight ratio) are mixed uniformly to prepare the sibutramine base oil solution.

[0033] 3. Weighing by weight ratio of components, 25Kg of sibutramine alkali oil solution (25% by weight ratio), 20Kg of stearyl alcohol (20% by weight ratio), 10Kg of glycerin (10% by weight ratio), monoglycerin Ester 1Kg (weight ratio 1%), Tween 5Kg (weight ratio 5%), water 39Kg (weight ratio 39%). Mix sibutramine base oil solution with glycerin, monoglyceride, stearyl alcohol and water, heat to 70-80°C with vigorous stirring or vigorous shaking, disperse and emulsify into an emulsion, cool to room temperature to form a c...

preparation Embodiment 3

[0035] 1. Choose an oil-soluble sibutramine such as sibutramine base.

[0036] 2. According to the weight ratio of the components, sibutramine base 25Kg (weight ratio 25%), simethicone oil 9Kg (weight ratio 9%), white oil 21Kg (weight ratio 21%), olive oil 10Kg (10% by weight ratio), 30Kg vitamin E (30% by weight ratio), and 5Kg essence (5% by weight ratio) are uniformly mixed to prepare the sibutramine base oil solution.

[0037] 3. Weighing by weight ratio of components, 0.1Kg of sibutramine alkali oil solution (0.1% by weight ratio), 1Kg of cetyl alcohol (1% by weight ratio), 1Kg of Tween (1% by weight ratio) , Water 97.9Kg (weight proportion 97.9%). Mix the sibutramine alkali oil solution with cetyl alcohol, Tween and water, heat to 70-80°C with vigorous stirring or vibration, disperse and emulsify into an emulsion, and cool to room temperature to form a milk.

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PUM

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Abstract

An exterior-applied medicine or health-care product for losing weight is prepared from sibutramine (0.1-25 wt.%), osmotic aid (0-15), VE (0-30), essence (0-20) and oily solvent (dimethyl silicon, oil, white oil, or olive oil) through preparing oily solution of sibutramine (0.1-2.5%) and proportionally mixing it with moistening agent (0-10%), emulsifier (1-6%), amend ment (1-20%) and water (the rest).

Description

technical field [0001] The invention relates to a weight-loss external product, which relates to a weight-loss external drug or a weight-loss external health care product. Sibutramine hydrochloride is a weight-loss drug for oral administration. It is very slightly soluble in water and oil solvents, but easily soluble in some lower alcohols, such as methanol and ethanol, so it is not easily absorbed by the human body. The present invention uses oil-soluble sibutramine, such as sibutramine base, etc., to be formulated into oil solution, or further processed into cream, milk, etc., and used as external products for weight loss or external health care products for weight loss. Background technique [0002] Due to the rapid economic development and the great improvement of material living standards, the intake of fat, sugar, and protein in people's diet has increased, and the corresponding physical labor and activity have decreased, resulting in energy intake greater than energy ...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61P3/04
Inventor 曾仲韬
Owner 曾仲韬
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