Artificial neural tube

A technology of artificial nerve and microfibrosis, applied in the field of artificial neural tube, can solve the problem of not developing an artificial spinal canal for spinal cord regeneration, etc.

Inactive Publication Date: 2002-07-24
TAPIC INT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on the above findings, it has been concluded that the spinal cord can be regenerated by inducing accurate alignment of the regenerated tissue area even in the spinal cord, but no artificial spinal canal capable of regenerating the spinal cord has actually been developed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0036] Weave polyglycolic acid (PGA) fibers (φ: 0.1mm) into a cylindrical shape, and prepare a polyglycolic acid mesh tube (mesh aperture: about 10-20 μm) with a length of about 10 mm, an inner diameter of about 4-5 mm, and a thickness of about 1 mm. The surface was hydrophilized by plasma discharge treatment, then immersed in a 1N hydrochloric acid solution containing 1.0% by weight of pig skin-derived enzyme-soluble collagen, and then air-dried to coat the inside of the mesh tube with the collagen hydrochloric acid solution. Outside (Of course, the collagen hydrochloric acid solution is also filled into the inside of the mesh. Wherein, the dipping and air-drying operations are repeated 10 times).

[0037] Next, after thermal dehydration and cross-linking treatment (140°C×24hr) was performed on the tube having the above-mentioned collagen coating layer on the inside and outside, the above-mentioned collagen hydrochloric acid solution was flowed into the inner cavity, and it wa...

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Abstract

The present invention is to provide an artificial tube for nerve which remains in a body until a nerve regenerates, does not remain in the body as a foreign body after regeneration of the nerve, induces axons regenerated from severed nerve stumps, promotes infiltration of blood capillaries from the body and promotes regeneration of nerve tissue, and a method for producing the same. The artificial tube for nerve has fine fibrous collagen bodies (30) in the lumen of a tube comprised of a biodegradable and absorbable material, the voids inside the fine fibrous collagen bodies being filled with laminin.

Description

technical field [0001] The present invention relates to artificial nerve tubes. Background technique [0002] When the peripheral nerve is severed during surgery or due to trauma, first try to directly anastomose the severed peripheral nerves. However, in most cases, the severed nerve cannot be accurately and directly anastomosed, and sometimes it is left as it is. Therefore, the nerve that wants to regenerate to the peripheral side is blocked by connective tissue, etc., and cannot reach the severed part of the peripheral nerve, forming a neuroma at the severed end, and stopping regeneration. There are sequelae. In cases where direct anastomosis cannot be performed, peripheral nerves whose functions are not important are sometimes partially removed by the same patient and autografted to the cut site of the nerves. However, even with this method, the nerve function cannot be fully restored in many cases, and the function of the transplanted nerve is often reduced. [0003...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/02A61F2/04A61L27/18A61L27/22A61L27/24A61L27/58
CPCA61L27/58A61F2/04A61L27/24A61L27/18A61F2210/0004A61L27/227A61L2430/32C08L67/04
Inventor 清水庆彦
Owner TAPIC INT
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