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Methods and compositions for reducing UV-induced inhibition of collagen synthesis in human skin

A composition, collagen biotechnology, applied in skin care preparations, drug combinations, skin diseases, etc.

Inactive Publication Date: 2001-07-11
RGT UNIV OF MICHIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as noted above, certain physiological differences between aged and photoaged skin are evident when the skin is subjected to histological and similar direct assays

Method used

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  • Methods and compositions for reducing UV-induced inhibition of collagen synthesis in human skin
  • Methods and compositions for reducing UV-induced inhibition of collagen synthesis in human skin
  • Methods and compositions for reducing UV-induced inhibition of collagen synthesis in human skin

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Embodiment Construction

[0040] Description of the preferred example

[0041] For all intents and purposes, collagen is the structural compound that supports the skin. Collagen precursor molecules are synthesized in the fibroblasts of the dermis; fibroblasts are the only collagen-producing cells in the dermis. Fibroblasts nourish the epidermis, and under normal conditions, they secrete large amounts of growth factors (such as FGF, IGF, and KGH among them) and produce procollagen. Procollagen enters the skin matrix and becomes structural collagen. Procollagen is a soluble collagen precursor secreted by fibroblasts, which is then converted extracellularly to insoluble collagen, the major extracellular structural component of human skin. After secretion, the carboxyl terminus of procollagen is cleaved to produce pN collagen precursor protein; subsequently, the amino terminus of this precursor protein is cleaved to produce insoluble collagen, which is incorporated into the extracellular skin matrix. Al...

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Abstract

Exposure of human skin to ultraviolet (UV) radiation from the sun not only induces the production of enzymes (matrix metalloproteinases) that degrade collagen, but also inhibits the synthesis of new collagen by inhibiting the synthesis of procollagen. This UV-induced inhibition of the synthesis of collagen can be prevented by the topical application of a retinoid or c-JUN inhibitor to the skin prior to its exposure to UV radiation.

Description

Background of the invention [0001] 1. field of invention [0002] The present invention relates to the field of photoprotection of human skin. More specifically, the present invention relates to compositions and methods for use topically to reduce, if not eliminate, inhibition of collagen synthesis in human skin following accidental and / or direct exposure to ultraviolet radiation. This inhibition may occur daily, but also after planned and prolonged recreational exposure to UV radiation in the sun. [0003] 2. state of the art [0004] Human skin is a complex organ that extends over the entire body. There are different types of skin on different parts of the body, for example the skin on the face is different from the skin on the scalp, and even the skin on the palms is different from the skin on the back of the hands. Although the type of skin can vary on a person's body, skin is generally composed of 2 main layers of tissue. The epidermis, the outermost layer, consist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/35A61K8/37A61K8/67A61K31/07A61K31/165A61K31/167A61K31/17A61K31/185A61K31/196A61K31/203A61K31/235A61K31/277A61K31/35A61K31/352A61K31/4439A61K31/517A61K31/522A61K45/06A61P17/02A61P43/00A61Q17/04A61Q19/08
CPCA61K2800/522A61K31/07A61K8/671A61K31/165A61K8/35A61Q19/08A61K8/37A61K31/185A61K31/352A61K31/203A61K31/4439A61K31/167A61Q17/04A61K31/277A61K31/517A61K31/196A61K31/522A61P17/02A61P43/00A61K31/20
Inventor G·J·费希尔J·J·沃里斯
Owner RGT UNIV OF MICHIGAN
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