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Preparing method for superfine Chinese medicine jellies

A technology of fine gel and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine pharmacy. It can solve the problems of rough appearance of the preparation, no mature product reports, poor transdermal absorption effect, etc., and achieve comprehensive drug effect, uniform size, and favorable dissolution and absorption. Effect

Inactive Publication Date: 2005-03-30
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional Chinese medicine gels are generally prepared from traditional Chinese medicine extracts, and traditional Chinese medicine gels prepared directly from raw medicinal powders have obvious defects such as rough appearance and poor transdermal absorption due to technical problems. No mature product reports

Method used

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  • Preparing method for superfine Chinese medicine jellies
  • Preparing method for superfine Chinese medicine jellies
  • Preparing method for superfine Chinese medicine jellies

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 The preparation of superfine pearl yellow Daisy gel

[0019] Follow the steps below (see Figure 1):

[0020] Take the same amount of raw medicinal materials pearl, bezoar, and Qingdai, grind them through a high-speed universal grinder, and then sieve them to obtain ordinary fine powders of 80-100 mesh, and send them to a ZHWY-100 airflow grinder for grinding to obtain ultrafine powders of 30 μm. Sterilize with Co60. The process parameters of the jet mill are: air consumption 1~3m 3 / min, crushing pressure 0.8~1.2Mpa, feeding pressure 0.5~0.8Mpa, feeding speed 2~4kg / h.

[0021] Grind 4 g of borneol into fine powder, take 30 g of the main drug of superfine medicinal material powder, mix the two, add 100 g of propylene glycol, disperse and grind to obtain a drug dispersion.

[0022] Take 2g of antioxidant EDTA-2Na, take 1g of preservative ethylparaben, mix them, add appropriate amount of water to dissolve, add 12.5g of Carbomer-940, stir and swell, and adjust ...

Embodiment 2

[0025] Embodiment two transdermal absorption effect test of traditional Chinese medicine ultrafine gel

[0026] The test object is the superfine Zhuhuangdai gel, which is a new preparation based on Zhuhuangsan. Huangdai gel and Zhuhuang powder were tested for transdermal drug release in vitro.

[0027] Take three pieces of fresh mouse skin with the same area, remove the subcutaneous fat, and evenly apply 1g of ultra-fine Zhuhuangdai gel with a drug content of 3%, 1g of ordinary Zhuhuangdai gel, and corresponding doses on the cuticles of the three skins. For Zhuhuang powder, the Franz diffusion cell was used for the test, and the bile acid content was measured by taking samples from the pool at regular intervals, and the cumulative drug release at different times was calculated by the specific Higuchi formula, and a curve was obtained, as shown in Figure 2.

[0028] In Figure 2, it can be seen from Figure 2 that the cumulative permeation volume per unit area of ​​the three pre...

Embodiment 3

[0029] Example 3 The curative effect test of ultrafine gel

[0030] Get 8 rabbits, use 90% carbolic acid to treat the oral mucosa of the rabbits, burn the upper, lower, left, and right four parts of the oral cavity of each rabbit simultaneously, and form four circular ulcers with a diameter of 2mm, and make the oral cavity of the rabbits. Mucosa model. Randomly divide 4 ulcers of the same rabbit into Zhuhuangsan group, ordinary Zhuhuangdai gel group, ultra-fine Zhuhuangdai gel group and blank control group for treatment. medicine. The complete recovery time was recorded for statistical processing. The results are shown in the table below

[0031] Effects of different dosage forms of drugs on the healing time of oral ulcers in rabbits (days)

[0032] Group Number of animals (only) Healing time (days)

[0033] Zhuhuang powder group 8 4.38±0.74 *

[0034] Ordinary Daisy Pearl gel group 8 4.25±0.89 *

[0035] Superfine pearl yellow Daisy gel group 8 3.88±0.83 **

[0036...

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Abstract

A process for preparing the superfine gel of raw Chinese-medicinal materials includes such steps as pulverizing to obtain superfine powder, sterilizing, adding propanediol, grinding, dissolving carbomer, EDTA-2Na and mycosten in water, swelling to become gel matrix, mixing with the superfine medicine dispersed liquid, adding nitrone and distilled water and stirring. Its advantages are no loss of active components and quick release.

Description

(technical field) [0001] The invention relates to a preparation method of a traditional Chinese medicine gel, in particular to a method for preparing an ultrafine gel of an original traditional Chinese medicine, and belongs to the field of traditional Chinese medicine pharmacy. (Background technique) [0002] The 2000 edition of "Chinese Pharmacopoeia" defines the gel in the (two) general rules: "The gel refers to the homogeneous, suspension or emulsion type latex thick liquid or semi solid preparations." [0003] Gel can be administered through mucosal parts, such as oral cavity, nasal mucosa, eye mucosa, rectal mucosa, uterus and vaginal mucosa, etc., to treat local or systemic effects. This method of administration is convenient and can avoid The first-pass effect of the liver has certain characteristics of targeting effect, and the curative effect is remarkable. Therefore, in recent years, the medical circle pays more and more attention to the research and development ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00
Inventor 郭立玮袁红宇傅廷明詹秀琴
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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