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1,6-fructostrontium biphosphate compounds and their preparing process and medical application

A technology of strontium salt compound and fructose diphosphate, applied in 1 field, can solve the problem of huge therapeutic dose

Inactive Publication Date: 2004-09-01
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the therapeutic dose of the drug is too large

Method used

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  • 1,6-fructostrontium biphosphate compounds and their preparing process and medical application
  • 1,6-fructostrontium biphosphate compounds and their preparing process and medical application
  • 1,6-fructostrontium biphosphate compounds and their preparing process and medical application

Examples

Experimental program
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Effect test

example 1

[0061] Dissolve 1.2kg of glucose, 0.4kg of sodium dihydrogen phosphate, 0.9kg of disodium hydrogen phosphate, and 0.1kg of magnesium chloride in 10L of water, heat to 37°C, add 1kg of brewer’s yeast and 600ml of toluene, stir at 37°C for 3.5 hours, and use 6N Adjust the pH to 2.0-2.5 with hydrochloric acid to stop the reaction, filter, dilute the filtrate 5 times with distilled water, adsorb on anion exchange resin HD-30, wash with 0.02N hydrochloric acid until the phosphate content of FDP is less than 0.05g / L, then use 0.5N hydrochloric acid to elute When the FDP content is less than 1g / L, collect 22L of eluate, FDPH 4 The concentration is 24g / L, and the eluate is dechlorinated with a nanofiltration membrane, concentrated, and the concentrated solution is collected. The FDP content in the concentrated solution is measured to be 86g / L, and the volume is 5.8L. Add 452g of strontium acetate and stir for 30 minutes. , concentrated in vacuo, added 300g of medicinal activated carbo...

example 2

[0071] Dissolve 1.2kg of glucose, 0.4kg of sodium dihydrogen phosphate, 0.9kg of disodium hydrogen phosphate, 0.1kg of magnesium chloride, 0.025Kg of ammonium chloride, and 0.04Kg of potassium chloride in 10L of water, heat to 37°C, add 1kg of brewer’s yeast and 600ml of toluene, stirred at 37°C for 3.5 hours, adjusted the pH to 2.0-2.5 with 6N hydrochloric acid to stop the reaction, filtered, diluted the filtrate 5 times with distilled water, adsorbed on anion exchange resin HD-30, washed with 0.02N hydrochloric acid until the phosphate content of FDP was less than 0.05g / L, use 1N sodium chloride to elute until the FDP content is less than 1g / L, collect 23L of the eluate, the concentration is 22.8g / L, concentrate in vacuo, add 300g of activated carbon for decolorization, add 2 times the volume of the solution in alcohol for desalination , suction filtration, the filtrate was washed 3 times with 0.5 times the volume of 75% alcoholic water, poured off the upper alcohol aqueous s...

example 3

[0079] Dissolve 120g of glucose, 40g of sodium dihydrogen phosphate, 90g of disodium hydrogen phosphate, and 10g of magnesium chloride in 1L of water, heat to 37°C, add 100g of brewer’s yeast and 60ml of toluene, stir at 37°C for 3.5 hours, and adjust the pH to 2.0-2.5 Stop the reaction, filter, dilute the filtrate 5 times with distilled water, adsorb on anion exchange resin HD-30, wash with 0.02N hydrochloric acid until the phosphate content of FDP is less than 0.05g / L, then use 0.5N hydrochloric acid to elute until the FDP content is less than 1g / L, the eluate was filtered with a nanofiltration membrane with a molecular weight cut-off of 200, and the macromolecular solution was collected. The FDP content in the filtrate was measured to be 92g / l, and the volume was 574ml. Add 30.1 g of strontium acetate to this solution, stir and react for 4 hours, add 2.5 times the volume of alcohol in the solution, and stir for 15 minutes, vacuum filter, wash with a small amount of 80% alcoh...

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Abstract

The present invention relates to 1,6-fructostronitium biphosphate, compounds, their preparing process and their medical application. The said compounds can be used for treating ostroporisis, bone fracture, shifting bone cancer and impotence.

Description

technical field [0001] The present invention relates to 1,6-diphosphate fructose strontium salt series compounds, a method for preparing the compounds, a composition containing the compounds and a treatment method using the compounds. technical background [0002] The compound of the present invention is a new compound capable of reducing the activity of osteoclasts, stimulating bone formation and increasing bone density of bone calcification, promoting the deposition of calcium in bones and teeth, and having good therapeutic or preventive effects on osteoporosis. Osteoporosis can be caused by a variety of reasons, among which primary osteoporosis (primaryosteoporosis POP) refers to the osteoporosis that occurs in aging or women after menopause. It is a systemic disease characterized by a decrease in bone mass per unit volume, insufficient production of bone organic components, and secondary reduction in calcium salt deposition. Clinically, it may be asymptomatic, or it may...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/70A61P15/10A61P19/08A61P19/10A61P35/00C07H11/04
Inventor 欧阳平凯应汉杰赵谷林徐燚程艳菊
Owner NANJING TECH UNIV
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