Starch-absorbable hemostatic material and preparation method thereof

Abstract

The invention provides an absorbable starch hemostatic material which is prepared by taking composite starch as a raw material, carrying out alkali and inorganic salinization treatment and then carrying out reversed-phase microemulsion reaction, the composite starch comprises one or more of modified starch and cellulose, and natural starch. Two starch-based materials, namely modified starch and natural starch, particularly potato starch and sodium carboxymethyl starch are compounded as main raw materials, the main raw materials are subjected to alkalization treatment and reversed-phase microemulsion reaction to obtain hemostatic microspheres in a certain particle range, and the hemostatic microspheres are refined, purified, endotoxin-removed and sterilized to obtain a final product. The obtained product has high water absorption capacity and water absorption speed, is good in biocompatibility, can be used for rapid hemostasis of various wounds, can be completely degraded, and is safe, non-toxic and convenient to operate. The method has the advantages of being simple in production process, mild in condition, low in production cost, rapid in hemostasis, short in in-vivo degradation time and the like.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an absorbable starch hemostatic material and a preparation method thereof. Background technique [0002] In emergencies such as battlefields, car accidents, natural disasters and surgical operations, uncontrollable massive blood loss is the leading cause of death. More than 50% of soldiers who died due to war were caused by uncontrollable blood loss from wounds, especially when the wounds were located in the chest, abdomen, head, neck and other parts that cannot be pressed to stop bleeding, accounting for 80% of the deaths. In natural disasters and traffic accidents, excessive blood loss of the injured is also an important cause of death that cannot be ignored. In various surgical operations, large area of ​​bleeding and oozing is a difficult problem often encountered by surgeons, and it is also an important reason for surgical failure. [0003] At present, the tradit...

AI Technical Summary

Problems solved by technology

Instantaneous is a kind of starch plant polysaccharide hemostatic material. Its hemostatic principle is generally believed that the surface micropores of polysaccharide particles act as molecular sieves. By concentrating blood platelets and other components, "instant gel" is produced, which plays a mechanical role. At the same time, carboxymethyl chitosan further improves the hemostatic effect by adsorbing platelets, coagulation factors and fibrin, but its compound carboxymethyl chitosan is an animal-derived material, and there are certain limitations. biosecurity risk

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