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Forsynthigenol extracting process

A technology for the extraction of forsythiaside, which is applied in the field of forsythiaside extraction technology, can solve the problems of inability, low efficiency, and difficult regeneration and reuse of separation materials, and achieves recyclable and reused prices, good selectivity, and benefits the effect of multiple uses

Inactive Publication Date: 2004-05-05
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above extraction methods are inefficient, use a large amount of toxic organic solvents, and the separation materials used are not easy to regenerate and reuse, so they cannot be transplanted and scaled up for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 500g of forsythia, pulverize through a 20-mesh sieve, and extract with 3 liters, 2 liters, and 2 liters of 80% ethanol solution by reflux three times, the first reflux for 2.5 hours, the second and third reflux for 2.0 hours respectively. Combine the extracts. Refrigerate for 12 hours. Filtrate, concentrate the filtrate under reduced pressure to obtain ethanol extract, extract the ethanol extract with water four times, 300ml each time, extract for two hours, and keep the temperature at 75°C. Combine the water extracts, stand for filtration, concentrate under reduced pressure, and separate the concentrated solution on a column. The column height is 63cm, the column diameter is 3.3cm, and the column packing is D 101 Macroporous adsorption resin. First rinse with water until the effluent becomes clear, then rinse with 25% ethanol at a rate of 20ml / min, and detect the effluent by thin-layer chromatography. The developer is: methyl ethyl ketone: ethyl acetate: formic...

Embodiment 2

[0025] Weigh 1Kg of forsythia, crush through a 20-mesh sieve, and extract by refluxing three times with 5 liters, 4 liters, and 4 liters of 85% ethanol solution, refluxing for 2.5 hours for the first time, and 2.0 hours for the second and third times respectively. Combine the extracts. Refrigerate for 12 hours. Filtrate, concentrate the filtrate under reduced pressure to obtain ethanol extract, extract the ethanol extract with water four times, 500ml each time, extract for two hours, and keep the temperature at 75°C. Combine the water extracts, stand for filtration, concentrate under reduced pressure, and separate the concentrated solution on a column. The column height is 60cm, the column diameter is 5.4cm, and the column packing is D 101 Macroporous adsorption resin. First rinse with water until the effluent becomes clear, then use 30% ethanol to rinse, the rinsing speed is: 25ml / min TLC to detect the effluent, the developer is: methyl ethyl ketone: ethyl acetate: formic a...

Embodiment 3

[0027] Weigh 1.5Kg of forsythia, crush through a 20-mesh sieve, and extract with 6 liters, 5 liters, and 5 liters of 82% ethanol solution by reflux three times, the first reflux for 2.5 hours, the second and third reflux for 2.0 hours respectively. Combine the extracts. Refrigerate for 12 hours. Filtrate, concentrate the filtrate under reduced pressure to obtain ethanol extract, extract the ethanol extract with water four times, 800ml each time, extract for two hours, and keep the temperature at 75°C. Combine the water extracts, stand for filtration, concentrate under reduced pressure, and separate the concentrated solution on a column. The column height is 75cm, the column diameter is 5.4cm, and the column packing is D 101 Macroporous adsorption resin. First rinse with water until the effluent becomes clear, then use 30% ethanol to rinse, the rinsing speed is: 25ml / min TLC to detect the effluent, the developer is: methyl ethyl ketone: ethyl acetate: formic acid: water: The...

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Abstract

A forsythigenol extracting process uses forsythia shell and leaf powder as raw material, ethanol and water as solvent and eluting agent, macroporous adsorbing resin as separating material, and active carbon as decoloring agent. The extracted forsythigenol product has forsythigenol content over 40%. The process of the present invention has the advantages of safe and non-toxic, cheap and reusable solvent, no environmental pollution, great extracting amount, high extracting efficiency, and being capable of being used in industrial production.

Description

Technical field: [0001] The invention relates to an extraction process for extracting the active ingredient forsythiaside from natural medicinal plant forsythia. Background technique: [0002] Forsythia is a deciduous shrub of Oleaceae Forsythia. The fruit is used as medicine, which has the functions of clearing away heat and detoxification, dispelling stagnation and swelling, antibacterial and inhibiting fungi. Forsythiaside is its main component. It not only has a strong inhibitory effect on eleven kinds of pathogenic bacteria such as Staphylococcus aureus, but also has the effect of inhibiting phosphodiesterase and fungi. Recently, we found that it also has a certain inhibitory effect on elastase. In view of its various biologically active functions, forsythiaside has broad application prospects in the fields of medicine and food as natural medicines, natural preservatives and natural antioxidants. So far, there have been no reports about extracting a large amount of fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07G3/00C07H1/08C07H15/18C07H15/26
Inventor 张立伟杨频王进东
Owner SHANXI UNIV
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