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Device for producing chloroquine phosphate and preparation process

A technology of chloroquine phosphate and a production device, which is applied in the directions of resisting vector-borne diseases, separation methods, filtration and separation, etc., can solve problems such as difficulty in concentrating pot and drying, affecting crystal quality, etc., to improve efficiency, improve preparation quality, reduce wasteful effect

Active Publication Date: 2022-08-02
JINGHUA PHARMA GRP NANTONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are many containers used in the refining process, and it is usually necessary to proceed to the next step after this operation is completed. After multiple conversions, the mixed chloroquine phosphate crude product is easy to contact with air and oxidize to produce other impurities, thereby affecting the quality of crystallization , and the crystallization step in the refining process is particularly important, and in general preparation equipment, considering that the concentration pot needs strong sealing, it is difficult to use the concentration pot to directly dry

Method used

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  • Device for producing chloroquine phosphate and preparation process
  • Device for producing chloroquine phosphate and preparation process
  • Device for producing chloroquine phosphate and preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] see Figure 1-Figure 3 As shown, the press-down assembly 120 includes a pressure plate 121, a first hydraulic rod 122 is arranged on the top of the pressure plate 121, a bracket 123 is arranged at the top of the first hydraulic rod 122, and the first hydraulic rod 122 is fixedly connected to the decolorizing pot 110 through the bracket 123. In addition, A filter element 150 is arranged between the decolorization pot 110 and the concentration pot 130 . In this embodiment, the filter element 150 is a filter screen, and the piston rod of the first hydraulic rod 122 is fixedly connected to the pressure plate 121 .

[0054] During preparation, first the first hydraulic rod 122 works to push the pressure plate 121 down through the piston rod until the top surface of the pressure plate 121 is lower than the top edge of the part where the decolorization pot 110 and the pressure plate 121 are attached. An injection cavity is formed between the top of the plate 121, purified wate...

Embodiment 2

[0057] Considering that the top of the platen 121 is in a horizontal state, the mixed solution attached to the outer wall of the platen 121 is not easy to flow down under the action of gravity, which often causes part of the mixed solution to adhere to its outer wall, thus causing waste. Please refer to Figure 5 As shown, this embodiment discloses another embodiment of the decolorizing pot 110 and the pressure plate 121. The top of the decolorizing pot 110 expands outward to form an expansion edge 112, and at this time, the pressure plate 121 moves down to a position where it fits with the inner wall of the decolorizing pot 110. That is, an injection cavity is formed between the outer wall of the pressure plate 121 and the inner wall of the expansion edge 112 at this time, and then the purified water and the crude chloroquine phosphate are put into the injection cavity, and activated carbon is added for decolorization. When the pressure plate 121 is lifted, the decolorized The...

Embodiment 3

[0059] Considering that the pressure plate 121 will continue to press down, there will be a pressure effect. If the pressure in the concentration pot 130 is controlled by this pressure, the efficiency of crystallization will be greatly improved. Therefore, this embodiment discloses another working mode of the filter element 150, please see Image 6 As shown, the filter element 150 is composed of a filter screen and an outer edge, the outer edge is fitted with the inner wall of the top opening of the concentrating pot 130, and the bottom of the outer edge is annularly provided with a plurality of elastic telescopic rods 151, so as to ensure that the outer edge is not affected by the After force, it can be reset. The specific telescopic rod 151 includes an inner rod and an outer rod, and a spring is arranged between the inner rod and the outer rod. Please refer to Figure 7 As shown, a pressing plate 1211 is provided at the bottom of the pressing plate 121, and the outer diamete...

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Abstract

The invention relates to the technical field of chloroquine phosphate production, in particular to a device for producing chloroquine phosphate and a preparation process. The device comprises a production device and a base arranged at the bottom of the production device, the base comprises a chassis, the production device comprises a decoloring pot and a concentrating pot, the decoloring pot is arranged at the top of the concentrating pot, a pressing assembly is arranged at the top of the decoloring pot, and a cooling shell is arranged at the bottom of the concentrating pot. According to the invention, mixing of purified water and the chloroquine phosphate crude product is realized through cooperation of the decolorizing pot and the pressure plate, a mixed solution flows into the top of the decolorizing pot from the top of the pressure plate through lifting of the pressure plate, and at the moment, pressure filtration of the mixed solution by a filter screen is realized through downward pressing of the pressure plate. Through cooperation of the bottom plate, the inner supporting plate and the outer supporting plate, the whole process is completed in a sealed environment, so that the purity of prepared chloroquine phosphate is guaranteed, and the preparation quality is improved.

Description

technical field [0001] The invention relates to the technical field of chloroquine phosphate production, in particular to a device for producing chloroquine phosphate and a preparation process. Background technique [0002] Chloroquine phosphate, also known as N', N'-diethyl-N4-(7-chloro-4-quinolinyl)-1,4-pentamethylenediamine diphosphate, is used for the treatment of chloroquine-sensitive malaria, vivax malaria; can also be used for the treatment of extraintestinal amebiasis, as well as anti-rheumatic effects. [0003] During preparation, the following steps are included: base preparation; salt formation; refining, wherein: [0004] Refining: Put the purified water and crude product into the decolorization pot, add activated carbon for decolorization, press into the concentration pot through the filter press, steam the water under reduced pressure, add ethanol to cool and crystallize after cooling down, discharge the material to the centrifuge to spin off, and spin off the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D36/00B01D15/10B01D9/02B01D29/03B01D29/82C07D215/46
CPCB01D36/00B01D15/10B01D9/02B01D9/0013B01D29/03B01D29/82C07D215/46Y02A50/30
Inventor 袁拥军张伟男秦俊俊滕飞顾健波郭茅丹
Owner JINGHUA PHARMA GRP NANTONG
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