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Broad-spectrum antibacterial antioxidant silk fibroin band-aid as well as preparation and application thereof

A silk fibroin and band-aid technology, applied in the medical field, can solve problems such as the inability to quickly and effectively solve the oxidative stress response and the undisclosed antioxidant properties of silk fibroin, so as to reduce the oxidative stress response of the wound surface, reduce the growth of bacteria, The effect of good air permeability

Pending Publication Date: 2022-08-02
SHENZHEN BAY LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The invention patent with the publication number CN105031714A discloses a band-aid with silk fibroin as the basic raw material, which has good antibacterial effect and can promote wound healing. However, the band-aid mainly utilizes the air permeability and biocompatibility of the silk fibroin film , the antioxidant properties of silk fibroin are not disclosed, and cannot quickly and effectively address trauma-induced oxidative stress

Method used

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  • Broad-spectrum antibacterial antioxidant silk fibroin band-aid as well as preparation and application thereof
  • Broad-spectrum antibacterial antioxidant silk fibroin band-aid as well as preparation and application thereof
  • Broad-spectrum antibacterial antioxidant silk fibroin band-aid as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] To prepare antibacterial and antioxidant silk fibroin band-aid sample 1, the specific steps are as follows:

[0104] (1) After heating and dissolving 2% β-cyclodextrin, mix it with 5% iodine in a volume ratio of 1:1, after sonicating for 30 minutes, evaporate the solvent to dryness, and collect the solid powder;

[0105] (2) Take 20 mL of 4% silk fibroin and treat it at 95°C for 2 h, add 1 mL of glycerol, stir mechanically for 10 min, then add 10 mL of 5% gelatin solution, stir mechanically for 10 min to form a white emulsion, then add 10 mL of 2% chitosan solution, Mechanical stirring for 30 minutes for standby;

[0106] (3) Take 1 g of the brown powder prepared in step (1), add 4 mL of deionized water, add it to the mixed solution prepared in step (2), stir for 30 minutes to obtain a light brown emulsion, and pour it into a 100×150 mm container, Placed at 4°C for 1 h, -20°C for 4h, -70°C for 6h, freeze-dried in a freeze dryer to obtain an antibacterial and antioxidan...

Embodiment 2

[0110] To prepare antibacterial and antioxidant silk fibroin band-aid sample 2, the specific steps are as follows:

[0111] (1) Mix 5% iodine with 2% polyvinylpyrrolidone solution, ultrasonicate for 30min, evaporate the solvent to dryness, and collect the solid powder;

[0112] (2) Take 20 mL of 4% silk fibroin and treat it at 95°C for 2 h, add 1 mL of glycerol, stir mechanically for 10 min, then add 10 mL of 5% gelatin solution, stir mechanically for 10 min to form a white emulsion, then add 10 mL of 2% chitosan solution, Mechanical stirring for 30 minutes for standby;

[0113] (3) Take 1g of the brown powder prepared in step (1), add 5mL of deionized water, add it to the solution prepared in step (2), stir for 10 minutes, pour it into a 100×150mm container, place at 4°C for 1h, -20 Place at ℃ for 4 h, -70 ℃ for 6 h, freeze-dried in a lyophilizer to obtain CTS-GEL / SF / PP-I sponge.

[0114] (4) The CTS-GEL / SF / PP-I sponge prepared in step (3) was completely swollen in water, p...

Embodiment 3

[0117] To prepare the antibacterial and antioxidant silk fibroin band-aid sample 3, the specific steps are as follows:

[0118] (1) After 2% β-cyclodextrin is heated and dissolved, it is mixed with 5% iodine in a volume ratio of 1:1, ultrasonicated for 30 minutes, and the solvent is evaporated to dryness to collect the solid powder;

[0119] (2) Take 20 mL of 4% silk fibroin and treat it at 95°C for 2 h, add 1 mL of glycerol, stir mechanically for 10 min, then add 10 mL of 5% polyvinyl alcohol solution, stir mechanically for 10 min to form a white emulsion, and then add 10 mL of 2% chitosan Sugar solution, mechanically stirred for 30 minutes for later use;

[0120] (3) Take 1g of the brown powder prepared in step (1), add 5mL of deionized water, add it to the solution prepared in step (2), stir for 10 minutes, pour it into a 100×150mm container, place at 4°C for 1h, -20 Place at ℃ for 4 hours, -70 ℃ for 6 hours, freeze-dried in a freeze dryer to obtain CTS-PVA / SF / CD-I sponge;...

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Abstract

The invention belongs to the technical field of medical treatment, and particularly relates to a broad-spectrum antibacterial and antioxidant silk fibroin band-aid as well as preparation and application thereof. The band-aid is composed of an inner isolating membrane, an outer viscous backing and a middle medicine layer, the medicine layer comprises silk fibroin, active iodine and auxiliary materials for preparing the medicine layer of the band-aid, and the mass ratio of the silk fibroin to the active iodine to the auxiliary materials is 1: (0.5-2): (0.1-10). The silk fibroin band-aid has broad-spectrum antibacterial and antioxidant effects, and wound healing is accelerated by reducing the oxidative stress reaction of a wound. The band-aid has the advantages of good moisture retention, strong air permeability, barrier property and easy uncovering property, and is a novel broad-spectrum antibacterial and antioxidant band-aid. The band-aid is prepared through freeze-drying, the preparation process is simple, the cost is low, the treatment effect is outstanding, the biological safety is good, the defects of existing commercially available band-aids are overcome, and the band-aid has remarkable medical value and industrialization potential.

Description

technical field [0001] The invention belongs to the technical field of medical treatment, and specifically relates to a broad-spectrum antibacterial and antioxidant silk fibroin band-aid and its preparation and application. Background technique [0002] Band-Aid is the most commonly used surgical drug in people's life. It has the functions of hemostasis and protection. It is suitable for skin abrasions, incisions and small areas, superficial wounds, little wound bleeding, and no need for sutures in daily life. Used for small wounds, it can play the role of emergency treatment, temporary hemostasis and wound protection, and can effectively prevent wound infection. [0003] Band-aids sold in traditional markets are divided into drug-free and drug-containing types. The drug-free Band-Aid is composed of a piece of tape with a small piece of gauze in the middle. Its structure is simple and its daily application is very limited; the drug-containing Band-Aids mainly include Yunnan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/18A61L15/24A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46
CPCA61L15/32A61L15/28A61L15/325A61L15/26A61L15/24A61L15/18A61L15/44A61L15/46A61L15/425A61L2300/106A61L2300/252A61L2300/404A61L2300/412A61L2300/602C08L89/00C08L5/08Y02A50/30
Inventor 彭琴钱智勇
Owner SHENZHEN BAY LAB
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