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Preparation method and application of licorice extract

A technology of licorice extract and licorice extract, which is applied in the field of preparation of licorice extract, can solve the problems of insolubles in water and gray scale detection, low content of insolubles in water, organic solvent residues, etc., to meet the requirements of pharmacopoeia, less residues, increase The effect of solubility

Active Publication Date: 2022-07-29
XINJIANG FUWO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the above-mentioned prior art discloses the preparation method of licorice extract and related bacteriostatic properties, it does not detect the water insoluble matter and gray scale of the obtained extract, and it is easy to propose using various organic solvents in the extraction process. Cause organic solvent residue, influence safety; Therefore, the preparation method of the licorice extractum that needs to provide a kind of active ingredient content high, water insoluble matter content is few, total gray scale is low, and safety is high

Method used

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  • Preparation method and application of licorice extract
  • Preparation method and application of licorice extract
  • Preparation method and application of licorice extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 A kind of preparation method of licorice extract

[0038] It includes the following steps:

[0039] (1) Raw material pretreatment: take 200 g of dried licorice raw material and pulverize it to 20 mesh, add a mixed solution of ethyl acetate (120 mL), ethanol (360 mL), and isopropanol (120 mL) in a volume ratio of 1:3:1 and spit Soak at temperature-60 for 5 hours. During the soaking process, it is necessary to ultrasonicate for 20 minutes under the condition of power of 600W and frequency of 25KHz, ultrasonic for 2 times, filter, and keep the filter residue for use;

[0040] (2) extraction: carry out water extraction with the filter residue obtained in step (1), and the water extraction times are 3 times; add 6 times of water for the first time, and cook for 2 hours; add 4 times of water for the second time, Decoct for 1 hour; add 3 times the amount of water for the third time, decoct for 1 hour, then filter, discard the filter residue, and keep the filtrate...

Embodiment 2

[0044] Embodiment 2 A kind of preparation method of licorice extract

[0045] It includes the following steps:

[0046] (1) Raw material pretreatment: take 200 g of dried licorice raw material and pulverize it to 20 mesh, add a mixed solution of ethyl acetate (300 mL), ethanol (750 mL), isopropanol (150 mL) in a volume ratio of 2:5:1 and ten Sodium dialkyl sulfate is soaked for 10 hours. During the soaking process, it is necessary to ultrasonicate for 30 minutes at a power of 500W and a frequency of 20KHz, ultrasonically for 2 times, filter, and keep the filter residue for future use;

[0047] (2) extraction: carry out water extraction with the filter residue obtained in step (1), the water extraction times are 3 times, add the water of 8 times of amount for the 1st time, decoct for 3 hours; add the water of 5 times of amount for the second time, Decoct for 2 hours; add 4 times the amount of water for the third time, decoct for 2 hours, then filter, discard the filter residue...

Embodiment 3

[0051] Embodiment 3 A kind of preparation method of licorice extract

[0052] It includes the following steps:

[0053] (1) Raw material pretreatment: take 200 g of dried licorice raw material and pulverize it to 20 mesh, add a mixed solution of ethyl acetate (200 mL), ethanol (500 mL), and isopropanol (100 mL) in a volume ratio of 2:5:1 and spit Soak at temperature -20 for 8 hours. During the soaking process, it is necessary to ultrasonicate for 20 minutes under the condition of power of 550W and frequency of 20KHz, ultrasonic for 2 times, filter, and keep the filter residue for use;

[0054] (2) extraction: carry out water extraction with the filter residue obtained in step (1), the water extraction times are 3 times, add the water of 8 times of amount for the 1st time, decoct for 3 hours; add the water of 5 times of amount for the second time, Decoct for 2 hours; add 3 times the amount of water for the third time, decoct for 2 hours, then filter, discard the filter residue...

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Abstract

The invention provides a preparation method and application of licorice extract, and relates to the technical field of extraction of effective components. Comprising the following steps: (1) raw material pretreatment: crushing a dried licorice raw material, adding an organic solvent and a surfactant, soaking, filtering, and reserving filter residues for later use; (2) extraction: performing water extraction on the filter residues obtained in the step (1), then filtering, discarding the filter residues, and retaining filtrate; and (3) concentrating the filtrate obtained in the step (2) into paste, and then drying to obtain the licorice extract. In the pretreatment step, licorice powder is soaked in an organic solvent and surfactant soaking mode, the solubility of ineffective components with different dissolving properties in the organic solvent is increased, and then the content of effective components in licorice extract is increased; and the content of insoluble substances in water and the total gray level of the obtained extract are obviously reduced.

Description

technical field [0001] The invention relates to the technical field of extraction of effective components of traditional Chinese medicines, in particular to a preparation method and application of a licorice extract. Background technique [0002] Licorice is the dried root and rhizome of the legume Glycyrrhiza uralensis Fisch. Licorice is sweet in nature, flat in taste, and returns to the heart, lung, spleen and stomach meridians. It has the functions of tonifying the spleen and nourishing qi, clearing heat and detoxifying, removing phlegm and relieving cough, relieving acute pain and reconciling various medicines. For weakness of the spleen and stomach, fatigue, palpitations, shortness of breath, cough with excessive phlegm, pain in the abdomen and extremities, carbuncle, swollen and sore, to relieve drug toxicity and potency. Licorice, a commonly used Chinese herbal medicine in clinical practice, has been included in many prescriptions. According to the theory of "the e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P1/14A61P11/10A61P11/14A61P29/00A61P39/02A61P9/06A61P17/02A61P35/00A61P31/04A61P31/12A61P25/00A61K125/00
CPCA61K36/484A61P1/14A61P11/10A61P11/14A61P29/00A61P39/02A61P9/06A61P17/02A61P35/00A61P31/04A61P31/12A61P25/00A61K2236/331A61K2236/333A61K2236/39A61K2236/51Y02A50/30
Inventor 李霞
Owner XINJIANG FUWO PHARMA
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