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Rabdosia eriocarpa heat-clearing and sore-throat-relieving tablet and preparation method thereof

A technology of Mao'exiang Chacai and Pharynx-relieving Tablets, which is applied in the field of preparation of Mao'exiangchacai Qingre-pharynx Tablets and Mao'exiang Chacai Qingre-pharynx Tablets. The effect of material fluidity and shortened onset time

Pending Publication Date: 2022-07-22
红云制药(昆明)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At the same time, the sugar-coating layer has been improved to solve the problems of stains and patient compliance during stable storage

Method used

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  • Rabdosia eriocarpa heat-clearing and sore-throat-relieving tablet and preparation method thereof
  • Rabdosia eriocarpa heat-clearing and sore-throat-relieving tablet and preparation method thereof
  • Rabdosia eriocarpa heat-clearing and sore-throat-relieving tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The present embodiment discloses a calyx fragrant tea and herbal heat-clearing and pharyngeal tablet, comprising a tablet core and a film-coating premix for wrapping the tablet core, and the tablet core comprises the following components in mass percentage: 45-81%, corn starch 1.58-37.58%, crospovidone 5%, sodium starch glycolate 8%, corn starch 0.42% for pulping, silicon dioxide 3%, magnesium stearate 1%; film coating The coating premix is ​​calculated by 3-5% of the mass of the tablet core;

[0043] Among them, the film coating premix is ​​calculated as 4% of the mass of the tablet core.

[0044] The film-coating premix is ​​a stomach-dissolving film-coating premix.

[0045] In order to facilitate those skilled in the art to further understand the present invention, the present invention will be further described below in conjunction with specific preparation examples.

[0046] The Maocalyxxiangchacaiqingreliyan tablet provided by the invention redesigns and optimiz...

specific Embodiment 1

[0074] (1) Granulation:

[0075] ①Preparation of adhesive: Take corn starch (for slurrying), add appropriate amount of warm water to wet, add boiling water to 17.5g, stir to make 6% starch slurry, cool to room temperature, add purified water to 17.5g before use g, after stirring evenly, set aside.

[0076] ② Add 45 parts of Calyx calyx tea extract powder, 37.58 parts of corn starch, 5 parts of sodium carboxymethyl starch, and 5 parts of crospovidone into the rapid mixing granulator, pre-mixed for 300s (stirring 20Hz), here Parts can be understood as a percentage by mass.

[0077] 3. After premixing, turn on the stirring speed of 20Hz, and slowly and evenly add 6% cornstarch slurry into the rapid mixing granulator from the pulping port;

[0078] ④ After adding slurry, granulate for 180s (stir 20Hz, granulating knife 20Hz), discharge and load on tray.

[0079] ⑤ Set the oven temperature to 60°C, and dry to a particle moisture content of 2.0% to 5.0%.

[0080] ⑥Use a swinging...

specific Embodiment 2

[0090] (1) Granulation:

[0091] ①Preparation of adhesive: Take corn starch (for slurrying), add appropriate amount of warm water to wet, add boiling water to 17.5g, stir to make 6% starch slurry, cool to room temperature, add purified water to 17.5g before use g, after stirring evenly, set aside.

[0092] ② Add 81 parts of Calyx calyx tea extract powder, 1.58 parts of corn starch, 5 parts of sodium carboxymethyl starch, and 5 parts of crospovidone into the rapid mixing granulator, and pre-mix for 300s (stir 20Hz).

[0093] 3. After premixing, turn on the stirring speed of 20Hz, and slowly and evenly add 6% cornstarch slurry into the rapid mixing granulator from the pulping port;

[0094] ④ After adding slurry, granulate for 180s (stir 20Hz, granulating knife 20Hz), discharge and load on tray.

[0095] ⑤ Set the oven temperature to 60°C, and dry to a particle moisture content of 2.0% to 5.0%.

[0096] ⑥Use a swinging granulator to install a 14-mesh sieve for granulation.

...

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Abstract

The invention discloses a rabdosia japonica heat-clearing and sore-throat-relieving tablet and a preparation method thereof. The rabdosia japonica heat-clearing and sore-throat-relieving tablet comprises a tablet core and a film coating premix for wrapping the tablet core, the tablet core is prepared from the following components in percentage by mass: 45 to 81 percent of rabdosia rubescens extract powder, 1.58 to 37.58 percent of corn starch, 5 percent of polyvinylpolypyrrolidone, 8 percent of carboxymethyl starch sodium, 0.42 percent of corn starch for pulp preparation, 3 percent of silicon dioxide and 1 percent of magnesium stearate; and the film coating premix accounts for 3-5% of the mass of the tablet core. The problem of disintegration time limit of the traditional Chinese medicine extract tablet is effectively solved, and the onset time of the product is shortened; meanwhile, a film coating is adopted for coating, so that the stability problem of the product in the storage process is solved, and the medication requirements of diabetics are met.

Description

technical field [0001] The present invention relates to the technical field of medicine preparation, in particular to a kind of calyx fragrant tea and vegetable Qingre Liyan tablet; in addition, the present invention also relates to a preparation method of a kind of hair calyx fragrant tea and vegetable clearing heat and pharynx tablet. Background technique [0002] Rabdosia eriocalyx (scientific name: Rabdosia eriocalyx) is a species of the genus Rabdosia eriocalyx. [0003] Perennial herb or shrub, native to Yunnan, western Sichuan, southern Guizhou and western Guangxi. Modern research has shown that calyx serrata mainly contains diterpenes, triterpenes and flavonoids, especially rich in enantio-kaurane diterpenes. The diterpenoids, as the main metabolites of the genus Caraway, have a wide range of biological activities, such as antibacterial, anti-inflammatory and anti-tumor. The ethanolic extracts and compounds of calyx fragrant tea have certain antiviral effects, espe...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/28A61K47/04A61K47/36A61K47/32A61K47/12A61P29/00A61P11/04
CPCA61K36/53A61K9/2095A61K9/2059A61K9/2027A61K9/2009A61K9/2013A61K9/2806A61K9/2893A61P29/00A61P11/04
Inventor 冯宝文李兴俊王朝军
Owner 红云制药(昆明)有限公司
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